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Diamine oxidase as a marker of intestinal integrity in acute appendicitis

  • Histamine Metabolism
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Abstract

In the operative treatment of appendicitis the so called negative appendectomy is an important issue because of its increased morbidity. From the hypothesis that the intestinal diamine oxidase activity is a suitable marker of mucosal integrity, the distribution pattern of the enzyme in appendices histologically classified as inflammed or not inflammed was studied. Histologically apparent inflammation of the appendix was connected with a significant reduction of diamine oxidase activity. The determination of this enzymic activity may be a simple and sensitive test for mucosal inflammation of the appendix even at a very early state. This could reduce the rate of negative appendectomies and influence thereby risk-cost-benefit calculations.

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Authors and Affiliations

  1. II. Department of Surgery, University of Cologne, Ostmerheimerstr. 200, 5000, Köln 91, FRG

    R. Menningen & N. Bönninghoff

  2. Institute of Pathology, University of Cologne, Ostmerheimerstr. 200, 5000, Köln 91, FRG

    M. Günther

  3. Department of Operative Medicine 1, University of Marburg, Ostmerheimerstr. 200, 5000, Köln 91, FRG

    C. -D. Stahlknecht

  4. Biochemical and Experimental Division of the II. Department of Surgery, University of Cologne, Ostmerheimerstr. 200, 5000, Köln 91, FRG

    I. Kubitza & J. Kusche

Authors
  1. R. Menningen
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  2. M. Günther
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  3. N. Bönninghoff
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  4. C. -D. Stahlknecht
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  5. I. Kubitza
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  6. J. Kusche
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Supported by a grant of the Deutsche Forschungsgemeinschaft Ku 464/2-2.

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Menningen, R., Günther, M., Bönninghoff, N. et al. Diamine oxidase as a marker of intestinal integrity in acute appendicitis. Agents and Actions 18, 38–40 (1986). https://doi.org/10.1007/BF01987976

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  • DOI: https://doi.org/10.1007/BF01987976

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