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Desensitization of rat peritoneal mast cells to substance P

  • Mast Cells and Neuropeptides
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Abstract

Rat peritoneal mast cells were pretreated for 10 min at 37°C with either substance P (SP, 3 or 6 μM) or compound 48/80 (37.5, 50 or 75 ng/ml). The effect of this pretreatment on the subsequent responsiveness of the cells to SP was studied. Both SP and compound 48/80 pretreatment of rat peritoneal mast cells inhibited the subsequent response of the cells to SP. The degree of inhibition produced by either SP or compound 48/80 was dependent on the concentration used to pretreat the cells. Inhibition of the response of the cells to SP was observed whether or not the pretreating agent was removed or remained in contact with the cells during the subsequent stimulation with SP. It is concluded that compound 48/80 and SP desensitize the cells to subsequent stimulation by SP and possible mechanisms for this are discussed.

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Authors and Affiliations

  1. Instituto di Farmacologia dell' Universita di Torino, Corso Raffaello, 30-10125, Torino, Italy

    C. Dianzani

  2. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    J. C. Foreman

Authors
  1. C. Dianzani
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  2. J. C. Foreman
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Dianzani, C., Foreman, J.C. Desensitization of rat peritoneal mast cells to substance P. Agents and Actions 23, 214–216 (1988). https://doi.org/10.1007/BF02142544

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  • DOI: https://doi.org/10.1007/BF02142544

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