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15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice

  • Autoimmunity
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Abstract

Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited.

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Authors and Affiliations

  1. Research Laboratories of Behringwerke AG, P.O.Box 1140, D-3550, Marburg/Lahn, FRG

    H. U. Schorlemmer & F. R. Seiler

  2. Pharmacology Kalle-Albert, Hoechst AG, D-6200, Wiesbaden, FRG

    R. R. Bartlett

Authors
  1. H. U. Schorlemmer
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  2. R. R. Bartlett
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  3. F. R. Seiler
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Schorlemmer, H.U., Bartlett, R.R. & Seiler, F.R. 15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice. Agents and Actions 34, 151–155 (1991). https://doi.org/10.1007/BF01993264

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  • DOI: https://doi.org/10.1007/BF01993264

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