Abstract
The physiology of the bone tissue is reviewed from the point of view of a clinical endocrinologist. The effect of the main calcium-regulating hormones and various local factors on the osteoblasts and osteoclasts is discussed. The aim of this review is to summarize the physiological and pathophysiological role of calcitonin, parathormone, vitamin D3, thyroid hormones, glucocorticoids, growth hormone and sex hormones on bone metabolism. The significance of endocrinological dysfunctions in the pathogenesis of osteoporosis, the most widespread metabolic bone disease, is emphasized. A theory concerning the pathogenetic role of androgen hormone deficiency in postmenopausal osteoporosis is discussed in detail.
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References
L. V. Avioli,Epidemiology of osteoporosis and its complications. In:Prevention of postmenopausal osteoporosis. (Ed. W. A. Peck) pp. 11–19, Parthenon, Camforth 1990.
M. Azria, The Calcitonins, pp. 48–58, Karger, Basel, 1989.
I. Holló, F. Szalay, K. Steczek and J. Szücs,Effect, of intravenous calcium load on the serum calcium level in post-menopausal osteoporosis. Acta Med. Acad. Sci. Hung.35, 53–59 (1978).
J. Zséli, J. Szũcs, K. Steczek, M. Szathmári, É. Kollin, Cs. Horváth, M. Guoth and I. Holló,Decreased calciotnin reserve in accelerated postmenopausal osteoporosis. Horm. Metab. Res.17, 696–697 (1985).
J. Zséli, P. Bösze, F. Szalay, J. Szücs, Cs. Horváth, É. Kollin, M. Szathmári, J. László and I. Holló,Calcitonin secretion in streak gonad syndrome (Turner's syndrome). Calcif. Tissue. Int.39, 297–299 (1986).
N. Agrawala and C. V. Gay,Specific binding of parathyroid hormone to living osteoclasts. J. Bone Min. Res.7, 531–539 (1992).
J. Selye,On the stimulation of new bone formation with parathyroid extract and irradiated ergosteron. Endocrinology16, 547 (1932).
F. Albright and E. C. Reifenstein, The Parathyroid Glands and Metabolic Bone Diseases. Williams and Wilkins, Baltimore, 1948.
E. F. Eriksen, D. S. Colvard and N. J. Berg,Evidence of estrogen receptors in normal human osteoblasts-like cells. Science241, 84–86 (1988).
M. J. Oursler, J. Pyfferoen, P. Osdoby, B. L. Riggs and T. C. Spelsberg,Osteoclasts express mRNA for estrogen receptor. J. Bone Min. Res.5 (suppl. 2) S203 (1990).
R. Lindsay, D. M. Hart, J. M. Aitken, E. B. MacDonald, J. B. Anderson and A. C. Clarke,Long term prevention of post-menopausal osteoporosis by oestrogen. Evidence for increased bone mass after delayed onset of oestrogen treatment. Lancet1, 1038–1041 (1976).
E. S. Orwoll, L. Stribrska, E. E. Ramsey and E. J. Keenan,Androgen receptors in osteoblasts-like cell lines. Calcif. Tissue Int.49, 183–187 (1991).
J. Szücs, I. Holló and M. Guoth,Calcitonin in pathological postmenopausal osteoporosis: Theory and practice. InOsteoporosis. (Eds. C. Christiansen, C. D. Arnaud, B. E. C. Nordin, A. M. Parfitt, W. A. Peck and B. L. Riggs) pp. 693–695, Dept. of Clinical Chemistry, Glostrup Hospital, Copenhagen, 1984.
I. Holló, M. Boross and J. Szücs,Effect of sex hormone deficiency on calcitonin induced hypocalcaemia. Akt. Gerontol.5, 609–616 (1975).
M. Boross, E. Morava, I. Gergely and I. Holló,Effects of prolonged aminoglutethimid and dehydroepiandrosterone treatment on rat bones. Akt. Gerontol.13, 15–20 (1983).
I. Holló and T. Fehér,Studies on postmenopausal osteoporosis. I. Urinary excretion of 17 ketosteroid fractions in postmenopausal osteoporosis. Acta Med. Acad. Sci. Hung20, 233–236 (1964).
I. Holló, F. Szalay, K. Steczek and J. Szücs,Effect of intravenous calcium load on the serum calcium level in postmenopausal osteoporosis. Acta Med. Acad. Sci. Hung.35, 53 (1978).
M. Szathmári and I. Holló,Androgene und Knochenstoffwechsel. Dtsch. med. Wschr.118, 204 (1993).
M. Szathmári, J. Szücs, T. Fehér and I. Holló,Dehydroepiandrosterone sulphate and bone mineral density. Osteoporosis Int. (in press).
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Szũcs, J. Osteoporosis from the point of view of the clinical endocrinologist. Agents and Actions 41, 80–83 (1994). https://doi.org/10.1007/BF01986398
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DOI: https://doi.org/10.1007/BF01986398