Skip to main content
Log in

Osteoporosis from the point of view of the clinical endocrinologist

  • Papers Presented at the Joint Meeting of the European Inflammation Society and Hungarian Biochemical Society Balatonaliga, Hungary, 19–21 May, 1993
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The physiology of the bone tissue is reviewed from the point of view of a clinical endocrinologist. The effect of the main calcium-regulating hormones and various local factors on the osteoblasts and osteoclasts is discussed. The aim of this review is to summarize the physiological and pathophysiological role of calcitonin, parathormone, vitamin D3, thyroid hormones, glucocorticoids, growth hormone and sex hormones on bone metabolism. The significance of endocrinological dysfunctions in the pathogenesis of osteoporosis, the most widespread metabolic bone disease, is emphasized. A theory concerning the pathogenetic role of androgen hormone deficiency in postmenopausal osteoporosis is discussed in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. L. V. Avioli,Epidemiology of osteoporosis and its complications. In:Prevention of postmenopausal osteoporosis. (Ed. W. A. Peck) pp. 11–19, Parthenon, Camforth 1990.

    Google Scholar 

  2. M. Azria, The Calcitonins, pp. 48–58, Karger, Basel, 1989.

    Google Scholar 

  3. I. Holló, F. Szalay, K. Steczek and J. Szücs,Effect, of intravenous calcium load on the serum calcium level in post-menopausal osteoporosis. Acta Med. Acad. Sci. Hung.35, 53–59 (1978).

    PubMed  Google Scholar 

  4. J. Zséli, J. Szũcs, K. Steczek, M. Szathmári, É. Kollin, Cs. Horváth, M. Guoth and I. Holló,Decreased calciotnin reserve in accelerated postmenopausal osteoporosis. Horm. Metab. Res.17, 696–697 (1985).

    PubMed  Google Scholar 

  5. J. Zséli, P. Bösze, F. Szalay, J. Szücs, Cs. Horváth, É. Kollin, M. Szathmári, J. László and I. Holló,Calcitonin secretion in streak gonad syndrome (Turner's syndrome). Calcif. Tissue. Int.39, 297–299 (1986).

    PubMed  Google Scholar 

  6. N. Agrawala and C. V. Gay,Specific binding of parathyroid hormone to living osteoclasts. J. Bone Min. Res.7, 531–539 (1992).

    Google Scholar 

  7. J. Selye,On the stimulation of new bone formation with parathyroid extract and irradiated ergosteron. Endocrinology16, 547 (1932).

    Google Scholar 

  8. F. Albright and E. C. Reifenstein, The Parathyroid Glands and Metabolic Bone Diseases. Williams and Wilkins, Baltimore, 1948.

    Google Scholar 

  9. E. F. Eriksen, D. S. Colvard and N. J. Berg,Evidence of estrogen receptors in normal human osteoblasts-like cells. Science241, 84–86 (1988).

    PubMed  Google Scholar 

  10. M. J. Oursler, J. Pyfferoen, P. Osdoby, B. L. Riggs and T. C. Spelsberg,Osteoclasts express mRNA for estrogen receptor. J. Bone Min. Res.5 (suppl. 2) S203 (1990).

    Google Scholar 

  11. R. Lindsay, D. M. Hart, J. M. Aitken, E. B. MacDonald, J. B. Anderson and A. C. Clarke,Long term prevention of post-menopausal osteoporosis by oestrogen. Evidence for increased bone mass after delayed onset of oestrogen treatment. Lancet1, 1038–1041 (1976).

    Article  PubMed  Google Scholar 

  12. E. S. Orwoll, L. Stribrska, E. E. Ramsey and E. J. Keenan,Androgen receptors in osteoblasts-like cell lines. Calcif. Tissue Int.49, 183–187 (1991).

    PubMed  Google Scholar 

  13. J. Szücs, I. Holló and M. Guoth,Calcitonin in pathological postmenopausal osteoporosis: Theory and practice. InOsteoporosis. (Eds. C. Christiansen, C. D. Arnaud, B. E. C. Nordin, A. M. Parfitt, W. A. Peck and B. L. Riggs) pp. 693–695, Dept. of Clinical Chemistry, Glostrup Hospital, Copenhagen, 1984.

    Google Scholar 

  14. I. Holló, M. Boross and J. Szücs,Effect of sex hormone deficiency on calcitonin induced hypocalcaemia. Akt. Gerontol.5, 609–616 (1975).

    Google Scholar 

  15. M. Boross, E. Morava, I. Gergely and I. Holló,Effects of prolonged aminoglutethimid and dehydroepiandrosterone treatment on rat bones. Akt. Gerontol.13, 15–20 (1983).

    Google Scholar 

  16. I. Holló and T. Fehér,Studies on postmenopausal osteoporosis. I. Urinary excretion of 17 ketosteroid fractions in postmenopausal osteoporosis. Acta Med. Acad. Sci. Hung20, 233–236 (1964).

    PubMed  Google Scholar 

  17. I. Holló, F. Szalay, K. Steczek and J. Szücs,Effect of intravenous calcium load on the serum calcium level in postmenopausal osteoporosis. Acta Med. Acad. Sci. Hung.35, 53 (1978).

    PubMed  Google Scholar 

  18. M. Szathmári and I. Holló,Androgene und Knochenstoffwechsel. Dtsch. med. Wschr.118, 204 (1993).

    PubMed  Google Scholar 

  19. M. Szathmári, J. Szücs, T. Fehér and I. Holló,Dehydroepiandrosterone sulphate and bone mineral density. Osteoporosis Int. (in press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Szũcs, J. Osteoporosis from the point of view of the clinical endocrinologist. Agents and Actions 41, 80–83 (1994). https://doi.org/10.1007/BF01986398

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01986398

Key words

Navigation