Skip to main content
SpringerLink
Log in

A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2)

  • II. Lipid mediators
  • Published:
Inflammation Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Xie W, Robertson DL, Simmons D. Mitogen-inducible prostaglanding G/H synthase: a new target for non-steroidal antiinflammatory drugs. Drug Dev Res 1992;25:249–65.

    Google Scholar 

  2. Aabakken L. Non-steroidal, antiinflammatory drugs—the extending scope of gastrointestinal side effects. Aliment Pharmacol Ther 1992;6:143–62.

    PubMed  Google Scholar 

  3. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. New Eng J Med 1984;310:563–72.

    PubMed  Google Scholar 

  4. Futaki N, Takahashi S, Yokoyama M, Arai S, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55–9.

    PubMed  Google Scholar 

  5. Gierse J, Hauser S, Creely B, Rangwala S, Koboldt C, Isakson P, et al. Expression and selective inhibition of human cyclooxygenase 1 and 2. Biochem J. In press.

  6. Summers MD, Smith GE. A Manual of Methods for baculovirus vectors and insect cell culture procedures. Texas Agric Exp Station Bull 1987;1555.

  7. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988;32:77–88.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Searle Research and Development, 60077, Skokie, IL, USA

    R. Huff, P. Collins & S. Kramer

  2. Department of Immunoinflammatory Diseases Research, Searle Research and Development, 63167, St. Louis, MO, USA

    K. Seibert, C. Koboldt, S. Gregory & P. Isakson

Authors
  1. R. Huff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Kramer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Seibert
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Koboldt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Gregory
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. Isakson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huff, R., Collins, P., Kramer, S. et al. A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2). Inflamm Res 44 (Suppl 2), S145–S146 (1995). https://doi.org/10.1007/BF01778304

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01778304

Keywords

Search

Navigation