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Does histamine have two vasodilator actions on the gastric mucosa?

  • Histamine and Kinins
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Abstract

It has been shown previously that there is a greater gastric mucosal blood flow response to histamine than to gastrin stimulation for similar acid secretory values. We have confirmed these observations under steady state conditions and also shown that the oxygen consumption depends on acid secretion in a similar way for both histamine and gastrin stimulation. Furthermore the degree of oxygen extraction from the gastric circulation is significantly less (p<0.001) during histamine stimulation than during gastrin stimulation. This supports the hypothesis that histamine causes a vasodilatation in the gastric mucosa in two ways, one may be linked to secretory activity and the other a pure dilator action.

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Authors and Affiliations

  1. Department of Physiology, Medical School, The University, NE1 7RU, Newcastle upon Tyne, England

    J. D. Reed & D. J. Sanders

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  1. J. D. Reed
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  2. D. J. Sanders
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Reed, J.D., Sanders, D.J. Does histamine have two vasodilator actions on the gastric mucosa?. Agents and Actions 5, 1–3 (1975). https://doi.org/10.1007/BF02027149

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  • DOI: https://doi.org/10.1007/BF02027149

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