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Pertussis vaccine oedema: An experimental model for the action of penicillamine-like drugs

  • Immunosuppression and Inflammation
  • Research Reports
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Abstract

A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection.d-Penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of antiinflammatory drugs from those liked-penicillamine which have a specific activity in rheumatoid arthritis.

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Authors and Affiliations

  1. Department of Pharmacology, Leo Pharmaceutical Products, DK-2750, Ballerup, Denmark

    E. Arrigoni-Martelli, E. Bramm, E. C. Huskisson, D. A. Willoughby & P. A. Dieppe

  2. Department of Rheumatology and Experimental Pathology, St. Bartholomew's Hospital, EC.1, London

    E. Arrigoni-Martelli, E. Bramm, E. C. Huskisson, D. A. Willoughby & P. A. Dieppe

Authors
  1. E. Arrigoni-Martelli
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  2. E. Bramm
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  3. E. C. Huskisson
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  4. D. A. Willoughby
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  5. P. A. Dieppe
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Arrigoni-Martelli, E., Bramm, E., Huskisson, E.C. et al. Pertussis vaccine oedema: An experimental model for the action of penicillamine-like drugs. Agents and Actions 6, 613–617 (1976). https://doi.org/10.1007/BF01971579

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  • DOI: https://doi.org/10.1007/BF01971579

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