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Untersuchungen über die alkylierende Wirkung von14C-Methylnitrosoharnstoff und 1-14C-Äthylnitrosoharnstoff

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  • Anatomica, Histologica, Carcinologica
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Summary

Alkylation of RNA from brain, liver and kidney in rats after application of14C-methylnitrosourea and 1-14C-ethylnitrosourea was investigated. After administration of14C-methylnitrosourea the amount of 7-methylguanine in the RNA of brain and liver is about the same. Analogic experiments using 1-14C-ethylnitrosourea showed no alkylation of the RNA in the organs investigated. This leads to the conclusion that there is no direct correlation between the alkylation of RNA and organotropic carcinogenic activity of the compounds studied.

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Authors and Affiliations

  1. Institut für experimentelle Geschwulsterzeugung und-behandlung und Institut für Nuklearmedizin, Deutsches Krebsforschungszentrum, 69 Heidelberg, Deutschland

    F. W. Krüger, H. Ballweg & W. Maier-Borst

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  1. F. W. Krüger
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  2. H. Ballweg
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  3. W. Maier-Borst
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Additional information

Herrn Professor Dr.O. Eichler zum 70. Geburtstag gewidmet.

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Krüger, F.W., Ballweg, H. & Maier-Borst, W. Untersuchungen über die alkylierende Wirkung von14C-Methylnitrosoharnstoff und 1-14C-Äthylnitrosoharnstoff. Experientia 24, 592–593 (1968). https://doi.org/10.1007/BF02153793

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  • DOI: https://doi.org/10.1007/BF02153793

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