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Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier

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  • Chimica. Biochimica. Biophysica
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Zusammenfassung

Das in vivo leicht hydrolysierbare 0, 0, 0-Triacetat und das zyklische Brenzkatechin-carbonat desl-Noradrenalins setzen im Herzen der Maus tritiiertes Noradrenalin frei. Beide Derivate sowie das 0, 0, 0-Trimethylsilyl-l-noradrenalin-7-3H, sind genügend lipophil, um leicht die Liquorschranke zu überschreiten, wo sie im Zentralnervensystem langsam tritiiertes Noradrenalin freisetzen. Solche Noradrenalin-Depot-Derivate sind möglicherweise von therapeutischem Interesse.

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Authors and Affiliations

  1. Laboratory of Chemistry, N.I.A.M.D., National Institutes of Health, 20014, Bethesda, Maryland, USA

    C. R. Creveling, J. W. Daly, T. Tokuyama (Associate in the Visiting Program of the U.S. Public Health Service) & B. Witkop

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  1. C. R. Creveling
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  2. J. W. Daly
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  3. T. Tokuyama
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  4. B. Witkop
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Creveling, C.R., Daly, J.W., Tokuyama, T. et al. Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier. Experientia 25, 26–27 (1969). https://doi.org/10.1007/BF01903871

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  • DOI: https://doi.org/10.1007/BF01903871

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