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Inhibition of succinic oxidase activity of beef heart mitochondria by a new fluorescent metabolite, zoanthoxantin

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Résumé

La zoanthoxantine est un nouveau composé aromatique, très fluorescent, caractérisé par le chromophore 1,3,5,7-tétrazacyclopent[f]azulen. On démontre l'action inhibitrice de ce métabolite sur une préparation submitochondriale de cœur de bœuf et le type d'inhibition en a été déterminé. On envisage, aussi la possiblité d'utiliser la zoanthoxantine comme indicateur moléculaire dans la zone d'inhibition.

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Rerefences

  1. L. Cariello, S. Crescenzi, G. Prota F. Giordano andL. Mazzarella, Chem. Comm.99 (1973).

  2. W. W. Wainio, in:The Mammalian Mitochondrial Respiratory Chain (Eds.B. Horecker, N. O. Kaplan, J. Marmur andH. A. Scheraga; Academic Press, New York and London 1970), p. 112.

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Authors and Affiliations

  1. Department of Biochemistry and Physiology, Stazione Zoologica, and Institute of Preventive Medicine, University, Naples, Italy

    L. Cariello & B. Tota

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  1. L. Cariello
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  2. B. Tota
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Additional information

We are indebted to Professor A. Azzi for helpful criticism and discussion.

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Cariello, L., Tota, B. Inhibition of succinic oxidase activity of beef heart mitochondria by a new fluorescent metabolite, zoanthoxantin. Experientia 30, 244–245 (1974). https://doi.org/10.1007/BF01934804

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  • DOI: https://doi.org/10.1007/BF01934804

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