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Interaction between dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and cyclic adenosine-3', 5'-monophosphate in neoplastic and normal human mammary tissue

  • Specialia Chimica, Biochimica
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Summary

When total DHEA, G-6-PDH activity, and c-AMP were determined in human neoplastic mammary tissue and corresponding normal tissue the G-6-PDH activity in the former tissue greatly exceeded that found in normal tissue. On the other hand, a remarkable decrease of total DHEA and c-AMP could be detected in cancer tissue, hinting at the participation of DHEA in the intracellular regulation of G-6-PDH and c-AMP levels.

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Authors and Affiliations

  1. Abteilung für Experimentelle Endokrinologie, Universitäts-Frauenklinik, Langenbeckstrasse 1, D-65, Mainz, Germany

    G. W. Oertel, P. Benes, G. Hoffmann & E. Schuy

Authors
  1. G. W. Oertel
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  2. P. Benes
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  3. G. Hoffmann
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  4. E. Schuy
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Oertel, G.W., Benes, P., Hoffmann, G. et al. Interaction between dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and cyclic adenosine-3', 5'-monophosphate in neoplastic and normal human mammary tissue. Experientia 31, 1124–1125 (1975). https://doi.org/10.1007/BF02326746

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  • DOI: https://doi.org/10.1007/BF02326746

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