Summary
Although glucose-6-phosphate dehydrogenase deficient individuals may suffer (sometimes fatally) from favism, a high incidence of this trait occurs in many Mediterranean populations. This apparent paradox is explained on the basis of a synergistic interaction between favism and G-6-PD deficiency that provides increased protection against malaria compared to that of the G-6-PD deficiency alone. This relationship is analogous to that between various hemoglobins and malaria in that there is selection for a more severe trait if it provides more protection against malaria.
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Huheey, J.E., Martin, D.L. Malaria, favism and glucose-6-phosphate dehydrogenase deficiency. Experientia 31, 1145–1147 (1975). https://doi.org/10.1007/BF02326760
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DOI: https://doi.org/10.1007/BF02326760