Summary
Chemotaxis of rabbit macrophages was inhibited in vitro by phenylbutazone and sodium salicylate, but not by other antiinflammatory agents. Other inhibitory compounds were colchicine, vincristine, PHA, Con A, iodoacetic acid, cytochalasin B, and EDTA. Some of these in vitro results contrast apparently with in vivo effects.
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References
J. F. Borel, Experientia29, 676 (1973).
S. Boyden, J. exp. Med.115, 453 (1962).
J. F. Borel, Int. Arch. Allergy39, 247 (1970).
R. Snyderman, L. C. Altman, M. S. Hausman andS. E. Mergenhagen, J. Immunol.108, 857 (1972).
H. U. Keller, M. W. Hess andH. Cottier, inChemotaxis: Its Biology and Biochemistry (Ed.E. Sorkin; Karger, Basel 1974), vol. 19, p. 112.
H. U. Keller, J. F. Borel, P. C. Wilkinson, M. W. Hess andH. Cottier, J. immun. Methods1, 165 (1972).
D. A. Boetcher andM. S. Meltzer, J. natn. Cancer Inst.54, 795 (1975).
M. E. Miller, inThe Phagocytic Cell in Host Resistance (Eds.J. A. Bellanti andD. H. Dayton; Raven Press, New York 1975), p. 295.
J. J. Rinehart, S. P. Balcerzak, A. L. Sagone, A. F. LoBuglio, J. clin. Invest.54, 1337 (1974).
M. Rabinovitch andM. J. Destefano, Expl Cell Res.88, 153 (1974).
K. Kumagai andS. Arai, J. reticul.-endothel. Soc.13, 507 (1973).
A. C. Allison, inChemotaxis: Its Biology and Biochemistry (Ed.E. Sorkin; Karger, Basel 1974), vol. 19, p. 191.
U. Bandmann, L. Rydgren andB. Norberg, Expl Cell Res88, 63 (1974).
G. M. Edelman, I. Yahara andJ. L. Wang, Proc. natn. Acad. Sci., USA70, 1442 (1973).
R. Snyderman andC. E. Stahl, inChemotaxis: Its Biology and Biochemistry (Ed.E. Sorkin; Karger, Basel 1974), vol. 19, p. 284.
R. C. Page, P. Davies andA. C. Allison, J. reticul.-endothel. Soc.15, 413 (1974).
R. J. North, J. exp. Med.134, 1485 (1971).
M. Di Rosa, L. Sorrentino andL. Parente, J. Pharm. Pharmac.24, 575 (1972).
C. Feurer andJ. F. Borel, inChemotaxis: Its Biology and Biochemistry (Ed.E. Sorkin; Karger, Basel 1974), vol. 19, 161.
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Borel, J.F., Feurer, C. Chemotaxis of rabbit macrophages in vitro: Inhibition by drugs. Experientia 31, 1437–1439 (1975). https://doi.org/10.1007/BF01923232
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DOI: https://doi.org/10.1007/BF01923232