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Allergic reactions, cyclic AMP and histamine release

  • Specialia
  • Haematologica, Immunologica
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Summary

Both isobutylmethylxantine and theophylline increased the level of cyclic AMP in the mast cell. Theophylline reduced the allergic histamine release, whereas isobutylmethylxynthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is too simple.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Copenhagen, 20, Juliane Maries Vej, DK-2100, Copenhagen Ø, Denmark

    P. Stahl Skov, A. Geisler, R. Klysner & S. Norn

Authors
  1. P. Stahl Skov
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  2. A. Geisler
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  3. R. Klysner
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  4. S. Norn
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Additional information

This work was supported by grants from the Danish Medical Research Council (Grant No. 512-5270) and from Lundbeckfonden.

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Skov, P.S., Geisler, A., Klysner, R. et al. Allergic reactions, cyclic AMP and histamine release. Experientia 33, 965–966 (1977). https://doi.org/10.1007/BF01951308

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  • DOI: https://doi.org/10.1007/BF01951308

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