Summary
Electron microscopy of the liver of methotrexate-treated psoriatic patients revealed junctional abnormalities consisting of detachment of desmosomal plaques between hepatocytes. Mitochondria anchoring desmosomal microfilaments were frequently noted.
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Acknowledgment. This work was supported in part by a grant from the Physicians' Services Incorporated Foundation, Toronto. The excellent technical assistance of Mrs Gezina Ilse and the invaluable secretarial help of Mrs Wanda Wlodarski are gratefully acknowledged
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Horvath, E., Kovacs, K., Ross, R.C. et al. Desmosomal abnormalities in the liver of methotrexate-treated psoriatics. Experientia 33, 1202–1204 (1977). https://doi.org/10.1007/BF01922329
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DOI: https://doi.org/10.1007/BF01922329