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Inhibitory effect of tiaramide on ADP-induced aggregation in rabbit platelets

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Summary

Tiaramide in 10−4 or 10−5 M depressed the ADP-induced aggregation of rabbit platelets using the turbidimetric method. In modified Chandler's loop method, tiaramide in the same concentration accelerated the restoration of the time course of disaggregation.

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References

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Authors and Affiliations

  1. Department of Pharmacology, Fukushima Medical College, 960, Fukushima, Japan

    S. Takano, T. Aikawa, T. Oishi, M. Goto, O. Tamura & T. Suzuki

Authors
  1. S. Takano
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  2. T. Aikawa
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  3. T. Oishi
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  4. M. Goto
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  5. O. Tamura
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  6. T. Suzuki
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Additional information

Acknowledgment. We are very grateful to Dr T. Takashima, Fujisawa Pharmaceutical Co. Ltd, for gifts of the pure tiaramide.

T. Aikawa, T. Oishi, M. Goto and O. Tamura are students of Fukushima Medical College.

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Takano, S., Aikawa, T., Oishi, T. et al. Inhibitory effect of tiaramide on ADP-induced aggregation in rabbit platelets. Experientia 34, 1063–1064 (1978). https://doi.org/10.1007/BF01915350

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  • DOI: https://doi.org/10.1007/BF01915350

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