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Isoguvacine, isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia

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Summary

The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. Muscimol was the only analogue more potent than GABA (molar potency ratio=5.08±0.707). The potency of isoguvacine was 0.23±0.026 and isonipecotic acid 0.011±0.0028. N.-methyl isoguvacine was <0.001 GABA.

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References

  1. T.N. Chase and J.R. Walters, in: GABA in Nervous System Function, p. 497. Ed. E. Roberts, T.N. Chase and D.B. Tower. Publ. Raven Press, New York 1976.

    Google Scholar 

  2. P. Krogsgaard-Larsen, G.A.R. Johnston, D. Lodge and D.R. Curtis, Nature, Lond.268, 53 (1977).

    Article  CAS  PubMed  Google Scholar 

  3. D.R. Curtis, A.W. Duggan, D. Felix and G.A.R. Johnston, Brain Res.32, 69 (1971).

    Article  CAS  PubMed  Google Scholar 

  4. S.J. Enna, J.F. Collins and S.H. Snyder, Brain Res.124, 185 (1977).

    Article  CAS  PubMed  Google Scholar 

  5. R.W. Olsen, in: Amino Acids as Chemical Transmitters. Ed. F. Fonnum, Publ. Plenum Press, New York, in press (1978).

    Google Scholar 

  6. N.G. Bowery and D.A. Brown, Br. J. Pharmac.50, 205 (1974).

    Article  CAS  Google Scholar 

  7. P.R. Adams and D.A. Brown, J. Physiol. Lond.250, 85 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. D.A. Brown and S. Marsh, J. Physiol., Lond.246, 24P (1975).

  9. L.L. Iversen and M.J. Neal, J. Neurochem.15, 1141 (1968).

    Article  CAS  PubMed  Google Scholar 

  10. N.G. Bowery and D.A. Brown, Nature New Biol.238, 89 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. N.G. Bowery, D.A. Brown, G.G.S. Collins, M. Galvan, S. Marsh and G. Yamini, Br. J. Pharmac.57, 73 (1976).

    Article  CAS  Google Scholar 

  12. M. Goodchild and M.J. Neal, Br. J. Pharmac.47, 529 (1973).

    Article  CAS  Google Scholar 

  13. H. Oediger and N. Joop, Ann. Chem.764, 21 (1972).

    Article  CAS  Google Scholar 

  14. D.A. Brown, M.J. Brownstein and C.N. Scholfield, Br. J. Pharmac.44, 651 (1972).

    Article  CAS  Google Scholar 

  15. N.G. Bowery, G.P. Jones and M.J. Neal, Nature, Lond.264, 281 (1976).

    Article  CAS  Google Scholar 

  16. P.M. Beart, G.A.R. Johnston and M.L. Uhr, J. Neurochem.19, 1855 (1972).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Pharmacology, St. Thomas's Hospital Medical School, SE1 7EH, London, England

    N. G. Bowery, J. F. Collins, A. L. Hudson & M. J. Neal

  2. School of Pharmacy, 29/39 Brunswick Square, WC1N 1AX, London, England

    N. G. Bowery, J. F. Collins, A. L. Hudson & M. J. Neal

  3. Department of Chemistry, City of London Polytechnic, 31 Jewry Street, EC3, London, England

    N. G. Bowery, J. F. Collins, A. L. Hudson & M. J. Neal

Authors
  1. N. G. Bowery
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  2. J. F. Collins
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  3. A. L. Hudson
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  4. M. J. Neal
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Bowery, N.G., Collins, J.F., Hudson, A.L. et al. Isoguvacine, isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia. Experientia 34, 1193–1195 (1978). https://doi.org/10.1007/BF01922953

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  • DOI: https://doi.org/10.1007/BF01922953

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