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Manganese prolongation of pentobarbital hypnosis in the male rat

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Summary

Following manganese treatment, pentobarbital hypnosis was prolonged in male rats. The maximal effect occurred from 1 to 3 days following manganese treatment and the threshold dose was found to be 3 mg Mn++/kg (i.p.).

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Authors and Affiliations

  1. Department of Pharmacodynamics and Toxicology, College of Pharmacy, University of Nebraska Medical Center, 68105, Omaha, Nebraska, USA

    M. J. Deimling & R. C. Schnell

Authors
  1. M. J. Deimling
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  2. R. C. Schnell
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Additional information

Acknowledgments. This work was supported by NIEHS Research Grant ES-02425. These data were submitted as part of a Ph.D. thesis to Purdue University, West Lafayette, Indiana, by M.J. Deimling.

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Deimling, M.J., Schnell, R.C. Manganese prolongation of pentobarbital hypnosis in the male rat. Experientia 37, 1322–1323 (1981). https://doi.org/10.1007/BF01948386

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