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Antidiuretic activities of substance P and its analogs

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Summary

Substance P (SP) and analogs, including 5 nucleoside (ARA or HRA)-peptides, were examined for antidiuretic activity in ethanolized rats. The activity was potent in the analogs embodying the C-terminal hexapeptide, weak in the nucleoside-pentapeptide, and negligible in the nucleoside-tetrapeptide. In addition, the activity was increased by acylation of the hexapeptide. The antidiuretic potencies were also compared with the hypotensive potencies.

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Authors and Affiliations

  1. Institute of Germfree Life Research, Nagoya University School of Medicine, 466, Nagoya, Japan

    M. Ukai, T. Nagase, M. Hirohashi & N. Yanaihara

  2. Shizuoka College of Pharmacy, 422, Shizuoka, Japan

    M. Ukai, T. Nagase, M. Hirohashi & N. Yanaihara

Authors
  1. M. Ukai
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  2. T. Nagase
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  3. M. Hirohashi
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  4. N. Yanaihara
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Additional information

This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and by a grant from the Imanaga Foundation, Nagoya, Japan.

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Ukai, M., Nagase, T., Hirohashi, M. et al. Antidiuretic activities of substance P and its analogs. Experientia 37, 521–523 (1981). https://doi.org/10.1007/BF01986174

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