Skip to main content
SpringerLink
Log in

Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation

  • Short Communications
  • New Methods and Apparatus
  • Published:
Experientia Aims and scope Submit manuscript

Summary

We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Refences

  1. Cittadini, G., Ingrami, D., Piola, F., and Sartoris, F., Radiologo16 (1977) 33.

    Google Scholar 

  2. Levin, A. R., Grossman, H., Schubert, E. T., Winchester, P., and Gilladoga, A., Am. J. Roentg.105 (1969) 777.

    Article  CAS  PubMed  Google Scholar 

  3. Mc Clennan, B. L., and Becker, J. A., Am. J. Roentg.113 (1971) 427.

    Article  CAS  PubMed  Google Scholar 

  4. Meyer, M. W., and Read, R. C., Radiology82 (1964) 630.

    Article  CAS  PubMed  Google Scholar 

  5. Rapoport, S. I., and Levitan, H., Am. J. Roentg.122 (1974) 186.

    Article  CAS  PubMed  Google Scholar 

  6. Almén, T., J. theor. Biol.24 (1969) 216.

    Article  PubMed  Google Scholar 

  7. Rosa, M., Radiologo19 (1980) 78.

    Google Scholar 

  8. Pitrè, D., and Tirone, P., Farmaco10 (1980) 826.

    Google Scholar 

  9. Pitrè, D., and Felder, E., Invest. Radiol.S15 (1980) 301.

    Article  Google Scholar 

  10. Dean, J. A., Chemical separation methods, Van Nostrand Reinhold, Wokingham, Berks 1969.

    Google Scholar 

  11. Morrison, G. H., Trace analysis. Physical Methods Interscience Publ., New York 1965.

    Google Scholar 

  12. Birks, J. B., The theory and practice of scintillation counting. Pergamon Press, Oxford 1964.

    Google Scholar 

  13. Bertolini, G., and Coche, M., Semiconductor detectors. North Holland, Amsterdam 1968.

    Google Scholar 

  14. Watt, D. E., and Ramsden, D., High sensitivity counting techniques. Pergamon Press, Oxford 1964.

    Google Scholar 

  15. Rapporto Finale di Sicurezza L.E.N.A., 1964.

  16. Price, W. J., Nuclear radiation detection. Mc Graw-Hill Book, New York 1958.

    Book  Google Scholar 

  17. Bonati, F., and Felder, E., 14th int. Congr. Radiol., Rio de Janeiro, Oct. 23–29, 1977.

  18. Garlaschi, G., and Sartoris, F., Radiologo19 (1980) 62.

    Google Scholar 

  19. Lasser, E. C., Radiology91 (1968) 63.

    Article  CAS  PubMed  Google Scholar 

  20. Leroux, G. F., J. Radiol. Électrol.56 (1975) 129.

    PubMed  Google Scholar 

  21. Mallarini, G., 7th int. Congr. of Lymphol., Florence, Oct. 28–Nov. 2, 1979.

Download references

Author information

Authors and Affiliations

  1. Istituto di Radiologia, Università degli Studi, Viale Benedetto XV, 10, I-16132, Genova, Italy

    O. Muratore, S. Saitta, G. Mallarini, P. Corvisiero & M. Sanzone

  2. Istituto di Science Fisiche, Università degli Studi, Viale Benedetto XV, 5, I-16132, Genova, Italy

    O. Muratore, S. Saitta, G. Mallarini, P. Corvisiero & M. Sanzone

  3. Istituto di Radiologia, Clinica Chirurgica, Università degli Studi, Viale Benedetto XV, 10, I-16132, Genova, Italy

    S. Saitta

Authors
  1. O. Muratore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Saitta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Mallarini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Corvisiero
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Sanzone
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgments. The authors wish to acknowledge use of the nuclear reactor offered by Prof. Orvini, L.E.N.A., Pavia and the invaluable suggestions provided by Prof. G. Cittadini and by Dr M. Gallorini. Moreover the authors wish to acknowledge the accurate revision of the English draft offered by Dr S. Raffanti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muratore, O., Saitta, S., Mallarini, G. et al. Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation. Experientia 39, 119–121 (1983). https://doi.org/10.1007/BF01960664

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01960664

Keywords

Search

Navigation