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Prolongation by selenium of pentobarbital hypnosis in the male rat

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Summary

Following treatment with sodium selenite, pentobarbital hypnosis was prolonged in male rats. The maximal effect occurred at 3–4 days following selenium treatment and the threshold dose for the effect was found to be 2.4 mg Se/kg (i.p.).

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Authors and Affiliations

  1. Department of Pharmacodynamics and Toxicology, College of Pharmacy, University of Nebraska Medical Center, 68105, Omaha, Nebraska, USA

    R. C. Schnell & J. L. Early

  2. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    R. C. Schnell & J. L. Early

Authors
  1. R. C. Schnell
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  2. J. L. Early
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Additional information

Acknowledgments. This work was supported by NIEHS Research Grant ES-02425 and a Purdue University Doctoral Fellowship for Black Students and Ethnic Minorities.

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Schnell, R.C., Early, J.L. Prolongation by selenium of pentobarbital hypnosis in the male rat. Experientia 39, 176–177 (1983). https://doi.org/10.1007/BF01958885

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