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Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells

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Summary

Glucan, a beta-1, 3 polyglucose, was administered to mice either 1 h before or 1 h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistantly exhibited a more rapid recovery of pluripotent stem cells and committed granulocyte, macrophage, and erythroid progenitor cells. This may partially explain the mechanism by which glucan also enhances survival in otherwise lethally irradiated mice.

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Authors and Affiliations

  1. Experimental Hematology Department, Armed Forces Radiobiology Research Institute, 20814, Bethesda, Maryland, USA

    M. L. Patchen, T. J. MacVittie & L. M. Wathen

Authors
  1. M. L. Patchen
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  2. T. J. MacVittie
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  3. L. M. Wathen
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Patchen, M.L., MacVittie, T.J. & Wathen, L.M. Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells. Experientia 40, 1240–1244 (1984). https://doi.org/10.1007/BF01946654

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