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Rat testes interstitial cell nuclei exhibit three distinct receptors for retinoic acid

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Summary

Purified nuclei from rat testes interstitial cells were incubated with an equimolar complex of [3H]retinoic acid and purified cellular retinoic acid-binding protein (cRABP) and with ATP. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and radiofluorographic analysis of the nuclear fractions indicated the presence of 3 highly labeled receptors for retinoic acid which were distinct from cRABP. These data demonstrate that retinoic acid binds to 3 novel nuclear acceptors of which cRABP does not appear to be a part.

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Authors and Affiliations

  1. The Department of Nutritional Sciences, The University of Connecticut, 06268, Storrs, Connecticut, USA

    F. O. Cope, K. L. Knox & R. C. Hall Jr

  2. The McArdle Laboratory for Cancer Research, The University of Wisconsin Medical School, N. Randall Ave., 53706, Madison, Wisconsin, USA

    F. O. Cope

Authors
  1. F. O. Cope
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  2. K. L. Knox
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  3. R. C. Hall Jr
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Additional information

Scientific contribution No. 1021, The Storrs Agricultural Experiment Station, The University of Connecticut, Storrs (Connecticut 06268, USA).

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Cope, F.O., Knox, K.L. & Hall, R.C. Rat testes interstitial cell nuclei exhibit three distinct receptors for retinoic acid. Experientia 40, 276–277 (1984). https://doi.org/10.1007/BF01947580

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  • DOI: https://doi.org/10.1007/BF01947580

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