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Morphine eye-drops reduce homatropine induced mydriasis in man

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  • Pharmacology, Toxicology
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Summary

In 7 healthy volunteers 4% morphine eye-drops, when administered to one eye, caused a miosis limited to that eye. In 7 other healthy volunteers morphine was administered into one eye after bilateral instillation of 0.5% homatropine opthalmic drops; the eye treated with morphine and homatropine showed a mydriasis less intense than the other eye treated only with homatropine. It is suggested that topical morphine locally affects sympathetic function by inhibiting noradrenaline release into the iris neuromuscular junction.

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References

  1. McCrea, F.D., Eadie, G.S., and Morgan, J.E., J. Pharmac. exp. Ther.74 (1942) 239.

    CAS  Google Scholar 

  2. Lee, H.K., and Wang, S.C., J. Pharmac. exp. Ther.192 (1974) 415.

    Google Scholar 

  3. Murray, R.B., and Tallarida, R.J., Eur. J. Pharmac.80 (1982) 197.

    Article  CAS  Google Scholar 

  4. Nomof, N., Elliot, H.W., and Parker, K.D., Clin. Pharmac. Ther.9 (1968) 358.

    Article  CAS  Google Scholar 

  5. Fanciullacci, M., Boccuni, M., Pietrini, U., and Sicuteri, F., Int. J. clin. pharm. Res.1 (1981) 139.

    Google Scholar 

  6. Knoll, J., Eur. J. Pharmac.39 (1976) 403.

    Article  CAS  Google Scholar 

  7. Enero, M.A., Eur. J. Pharmac.45 (1977) 349.

    Article  CAS  Google Scholar 

  8. Hanko, J.H., and Hardebo, J.E., Eur. J. Pharmac.51 (1978) 295.

    Article  CAS  Google Scholar 

  9. Cairnie, A.B., Kosterlitz, H.W., and Taylor, D.W., Br. J. Pharmac. Chemoter.17 (1961) 539.

    Article  CAS  Google Scholar 

  10. Henderson, G., Hughes, J., and Kosterlitz, H.W., Br. J. Pharmac.53 (1975) 505.

    Article  CAS  Google Scholar 

  11. Hughes, J., Kosterlitz, H.W., and Leslie, F.M., Br. J. Pharmac.53 (1975) 571.

    Article  Google Scholar 

  12. Fanciullacci, M., Pietrini, U., and Boccuni, M., Adv. Neurol.33 (1982) 365.

    CAS  PubMed  Google Scholar 

  13. Gerald, M.C., Chan, M.Y., and Pantil, P.N., Pharm. Res. Commun.8 (1976) 591.

    Article  CAS  Google Scholar 

  14. Sicuteri, F., Anselmi, B., and Del Bianco, P.L., Int. J. clin. pharm. Res.1 (1981) 145.

    Google Scholar 

  15. Fanciullacci, M., Boccuni, M., Pietrini, U., and Sicuteri, F., Eur. J. Pharmac.61 (1980) 319.

    Article  CAS  Google Scholar 

  16. Bellini, C., Boccuni, M., D'Egidio, P., Fanciullacci, M., Pietrini, U., and Sicuteri, F., Int. J. clin. pharm. Res.2 (1982) 55.

    Google Scholar 

  17. Allen, M., Thierman, J., and Hamilton, D., Can. J. appl. Sci.8 (1983) 98.

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Internal Medicine and Clinical Pharmacology, University Hospital, Viale Morgagni 85, I-50134, Florence, Italy

    M. Fanciullacci, F. Cangi, G. Gatto, M. Boccuni & U. Pietrini

Authors
  1. M. Fanciullacci
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  2. F. Cangi
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  3. G. Gatto
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  4. M. Boccuni
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  5. U. Pietrini
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Additional information

This work was partly supported by the CNR study group ‘Pain Control’. The authors wish to thank Dr Tendi of the Pharmacy of St. Maria Nuova Hospital, Florence, for the preparation of the eye-drops.

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Fanciullacci, M., Cangi, F., Gatto, G. et al. Morphine eye-drops reduce homatropine induced mydriasis in man. Experientia 40, 731–733 (1984). https://doi.org/10.1007/BF01949747

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  • DOI: https://doi.org/10.1007/BF01949747

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