Summary
Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for γ-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.
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Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments.
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Akaike, N., Hattori, K., Oomura, Y. et al. Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms. Experientia 41, 70–71 (1985). https://doi.org/10.1007/BF02005880
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DOI: https://doi.org/10.1007/BF02005880