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Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl

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Summary

The inhibitory effects of pargyline and quipazine on chicken growth hormone secretion were overcome by passive immunoneutralization of endogenous somatostatin (SRIF)-14 or SRIF-28(1–14)-like immunoreactivity. Administration of the specific antisera to control birds pretreated with 0.9% NaCl elevated the basal plasma GH concentrations. These results suggest that peptides with SRIF-14 or SRIF-28(1–14)-like immunoreactivity tonically inhibit GH secretion and are at least partially responsible for the inhibitory effects of pargyline and quipazine on GH release in immature domestic fowl.

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Authors and Affiliations

  1. Department of Physiology, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada

    S. Harvey & T. R. Hall

  2. Biovet Unit, Ciba Geigy, CH-1566, Saint Aubin, Switzerland

    S. Harvey & T. R. Hall

Authors
  1. S. Harvey
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  2. T. R. Hall
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Harvey, S., Hall, T.R. Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl. Experientia 43, 602–604 (1987). https://doi.org/10.1007/BF02126345

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  • DOI: https://doi.org/10.1007/BF02126345

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