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Retention of topical liposomal formulations on the cornea

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Summary

The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 μl drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery, liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.

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Authors and Affiliations

  1. Department of Pharmacology, Liposome Technology Inc., 1050 Hamilton Court, 94025, Menlo Park, California, USA

    T. A. McCalden & M. Levy

  2. Department of Pharmacology, Medical School, University of Nevada, 89557, Reno, Nevada, USA

    T. A. McCalden

Authors
  1. T. A. McCalden
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  2. M. Levy
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McCalden, T.A., Levy, M. Retention of topical liposomal formulations on the cornea. Experientia 46, 713–715 (1990). https://doi.org/10.1007/BF01939943

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  • DOI: https://doi.org/10.1007/BF01939943

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