Abstract
Protection from the deleterious effects of the interaction of environmental stress and salicylate by calcium supplement was investigated in 96 pigmented rats. Within a 2×2×4 factorial design, rats were assigned to groups defined by:A) ad lib access to 1) plain tap water, or 2) 50 mM calcium chloride solution;B) exposure to stressors consisting of daily 10 h periods of 1) 98 dB SPL noise, or 2) confinement precluding movements;C) daily injections of 233, 350, or 410 mg/kg of sodium salicylate or the saline vehicle. For subjects maintained on tap water, weight loss and mortality increased with salicylate levels, with all subjects dying in the group drinking water and injected with 410 mg/kg. Calcium protected all of the subjects in the noise stress group but not in the confined group.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Flower, R. J., Moncada, S., and Vane, J. R., in: The Pharmacological Basis of Therapeutics, p. 682. Eds A. G. Gilman, L. S. Goodman and A. Gilman. Macmillan, New York 1980.
Mongan, E., Kelly, P., Nies, K., Porter, W. W., and Paulus, H. E., JAMA226 (1973) 142.
Hinstridge, V., and Speight, T. M., Drugs42 Suppl 2 (1991) 8.
Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Speizer, F. E., and Hennekens, C. H., JAMA266 (1991) 521.
Meade, T. W., Am. J. Cardiol.65 (1990) 7C.
Jastreboff, P. J., Brennan, J. F., and Sasaki, C. T., in: Proceedings of the III International Tinnitus Seminar, Muenster, p. 95. Ed. H. Feldmann. Harsch Verlag, Karlsruhe 1987.
Jastreboff, P. J., Brennan, J. F., and Sasaki, C. T., Behav. Neurosci.102 (1988) 811.
Jastreboff, P. J., Brennan, J. F., and Sasaki, C. T., Laryngoscope98 (1988) 280.
Levy, G., Drug Metab. Rev.9 (1979) 3.
Levy, G., and Tsuchiya, T., N. Engl J. Med.287 (1972) 430.
McFadden, D., and Plattsmier, H. S., Hearing Res.9 (1983) 295.
McFadden, D., Plattsmier, H. S., and Pasanen, E. G., Am. J. Otolar.5 (1984) 235.
Brennan, J. F., and Jastreboff, P. J., Experientia45 (1989) 731.
Carson, S. S., Prazma, J., Pulver, S. H., and Anderson, T., Archs Otolar. Head Neck Surg.115 (1989) 1070.
Bancroft, B. R., Boettcher, F. A., Salvi, R. J., and Wu, J., Hearing Res.54 (1991) 20.
Saito, H., Yokoyama, A., Takeno, S., Sakai, T., Ueno, K., Masumura, H., and Kitagawa, H., Res. Commun. chem. Path. Pharmac.38 (1982) 209.
Ueno, K., Shimoto, Y., Yokoyama, A., Kitagawa, H., Takeno, S., Sakai, T., and Saito, H.. Res. Commun. chem. Path. Pharmac.39 (1983) 179.
Jastreboff, P. J., Nguyen, Q., Brennan, J. F., and Sasaki, C. T., in: Tinnitus 91. Proceedings IV International Tinnitus Seminar, Bordeaux, France, 1991, Eds J. Aran and R. Dauman. Kugler Publications, Amsterdam 1992.
Jastreboff, P. J., Nguyen, Q., and Sasaki, C. T., Assoc. Res. Otolar.14 (1991) 75.
Kelly, J. B., and Masterton, B., J. comp. physiol. Psychol.91 (1977) 930.
Durrant, J. D., and Lovrinic, J. H., in: Bases of Hearing Science, p. 52. Ed. J. P. Butler. Williams and Wolkins, Baltimore-London 1984.
Trinder, P., Biochem. J.57 (1953) 301.
Lindquist, E. F., Design and Analysis of Experiments in Psychology and Education, Riverside Press, Cambridge 1953.
Winer, B. J., Statistical Principles in Experimental Design, p. 907. McGraw-Hill, New York 1971.
Jastreboff, P. J., and Brennan, J. F., in: Tinnitus 91. Proceedings IV International Tinnitus Seminar, Bordeaux, France, 1991, p. 305. Eds J. Aran and R. Dauman. Kugler Publications, Amsterdam 1992.
Kellerhals, B., and Zogg, R., ORL J. Otorhinolar. relat. Spec.53 (1991) 331.
Misawa, M., Nishimura, T., Yanaura, S., Ueno, K., Igarashi, T., Sato, T., and Kitagawa, H. J. Pharmacobiodyn.8 (1985) 525.