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Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets

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Abstract

The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothiadiazine derivative, and diazoxide on86Rb outflow,45Ca outflow,45Ca uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the KATP channels.

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References

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Authors and Affiliations

  1. Laboratory of Pharmacology, School of Medicine, Brussels Free University 808, route de Lennik, B-1070, Brussels, Belgium

    M. -H. Antoine, M. Hermann, A. Herchuelz & P. Lebrun

  2. Department of Medicinal Chemistry, University of Liège, Belgium

    B. Pirotte, P. de Tullio & J. Delarge

Authors
  1. M. -H. Antoine
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  2. B. Pirotte
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  3. M. Hermann
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  4. P. de Tullio
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  5. J. Delarge
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  6. A. Herchuelz
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  7. P. Lebrun
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Antoine, M.H., Pirotte, B., Hermann, M. et al. Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets. Experientia 50, 830–832 (1994). https://doi.org/10.1007/BF01956464

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  • DOI: https://doi.org/10.1007/BF01956464

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