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The adenoma-carcinoma sequence of the colon and rectum

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Sozial- und Präventivmedizin

Summary

The Adenoma-Carcinoma Sequence of the Colon and Rectum Morphological and epidemiological arguments in favour of an adenoma-carcinoma concept of evolution in the development of colorectal cancers are presented. It is highly probable that most colorectal cancers arise in adenomas. Therefore detection and endoscopic removal of adenomas is a means of reducing the incidence of colorectal carcinomas.

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References

  1. Arminski, T.C. andD.W. McLean, Incidence and Distribution of Adenomatous Polyps of the Colon and Rectum based on 1000 Autopsy Examinations. Dis. Colon Rectum,7, 249–261, 1964.

    Google Scholar 

  2. Arnold, K. andH.F. Otto, Frühformen des kolorektalen Karzinoms. Therapiewoche,28, 5001–5009, 1978.

    Google Scholar 

  3. Berg, J.W. andM.A. Howell, The Geographic Pathology of Bowel Cancer. Cancer (Philad.),34, 807–814, 1974.

    Google Scholar 

  4. Bremer, C.G. andL.V. Ackermann, Polyps and carcinoma of the large bowel in South African Bantu. Cancer (Philad.),26, 991–999, 1970.

    Google Scholar 

  5. Correa, P., Strong, J.P., Reif, A. andW.D. Johnson, The epidemiology of colorectal polyps. Prevalence in New Orleans and International Comparisons. Cancer (Philad.),39, 2258–2264, 1977.

    Google Scholar 

  6. Enterline, H.T., Polyps and Cancer of the Large Bowel, In: Morson, B.C., Pathology of the Gastro-intestinal Tract. Current Topics in Pathology,63, 97–141, 1976.

  7. Fenoglio, C.M. andN. Lange, The anatomical precursor of colorectal carcinoma. Cancer (Philad.),34, 819–823, 1974.

    Google Scholar 

  8. Gilbertsen, C.A., Proctosigmoidoscopy and Polypectomie in reducing the Incidence of Rectal Cancer. Cancer (Philad.),34, 936–939, 1974.

    Google Scholar 

  9. Hertz, R.E., Deddish, M.R. andE. Day, Value of periodic examination in detecting cancer of the rectum and colon. Postgrad. Med.,27, 290–294, 1977.

    Google Scholar 

  10. Morson, B.C. andL.H. Sobin, Histological Typing of Intestinal Tumours. Internat. Histol. Classification of Tumors Nr. 15 WHO, Geneva, 1976.

    Google Scholar 

  11. Muto, T., Bussey, H.J.R. andB.C. Morson, The Evolution of Cancer of the Colon and Rectum. Cancer (Philad.),36, 2251–2270, 1975.

    Google Scholar 

  12. Muto, T., Ishikawa, K., Kino, I., Nakamura, K., Sugano, H., Bussey, H.J.R. andB.C. Morson, Comparative Histological Study of Adenomas of the Large Intestine in Japan and England, with Special Reference to Malignant Potential. Dis Colon Rectum,20, 11–16, 1977.

    PubMed  Google Scholar 

  13. Shamsuddin, A.K.M., Bell, H.G., Petrucci, J.V. andB.F. Trump, Carcinoma in situ and ”micro-invasive” Adenocarcinoma of Colon. Path. Res. Pract.,167, 374–379, 1980.

    PubMed  Google Scholar 

  14. Skinner, J.M. andR. Whitehead, Tumor-associated Antigens in Polyps and Carcinoma of the Human Large Bowel. Cancer (Philad.),47, 1241–1245, 1981.

    Google Scholar 

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Authors and Affiliations

  1. Institut für Pathologie, Kantonsspital, CH-9007, St. Gallen

    Friedrich J. Gloor

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  1. Friedrich J. Gloor
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Gloor, F.J. The adenoma-carcinoma sequence of the colon and rectum. Soz Präventivmed 31, 74–75 (1986). https://doi.org/10.1007/BF02091586

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