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Stability of plasma amiodarone levels during chronic oral therapy

  • Arrhythmias
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Summary

The variability of plasma amiodarone levels in 51 patients receiving chronic oral therapy over 4–53 (median 19) months was examined; 3–14 (median 5) plasma samples were obtained. After a loading dose, most patients received either 200mg or 400mg a day. Mean plasma amiodarone concentration was 1.2±0.6mg/l and mean plasma desethylamiodarone concentration, was 1.2±0.5mg/l. No relationship was seen between height and weight and plasma concentrations. Dose was a significant predictor of plasma level (p<0.01) although it was a poor predictor of steady state amiodarone concentration.

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Authors and Affiliations

  1. Cardiological Sciences, St. Georges Hospital Medical School, Cranmer Terrace, SW17 ORE, London, England

    Killian Robinson, John Mulrow & William McKenna MD, FACC

  2. Poisons Unit, Guy's Hospital, London, England

    Simon Walker & David Holt

  3. Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, England

    Atholl Johnston

Authors
  1. Killian Robinson
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  2. Atholl Johnston
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  3. Simon Walker
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  4. John Mulrow
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  5. David Holt
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  6. William McKenna MD, FACC
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Robinson, K., Johnston, A., Walker, S. et al. Stability of plasma amiodarone levels during chronic oral therapy. Cardiovasc Drug Ther 4, 529–530 (1990). https://doi.org/10.1007/BF01857765

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  • DOI: https://doi.org/10.1007/BF01857765

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