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Dehydro-thermally cross-linked collagen-poly(vinyl alcohol) blends: mechanical, biological and surface properties

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The mechanical, biological and surface properties of films, based on blends of soluble collagen and poly(vinyl alcohol), were investigated. Films prepared by casting were cross-linked by a dehydro-thermal treatment. The mechanical behaviour of the materials was studied by dynamic-mechanical thermal analysis. The biological properties of the films were evaluated by performing cytotoxicity and cytocompatibility in vitro tests. Surface characterization was carried out by X-ray electron spectroscopy. The results obtained indicate that these materials behave as two-phase systems and a remarkable enrichment of collagen in the surface with respect to the bulk was observed. Cytocompatibility tests show that the blending of the two polymers creates a better substrate for cell growth in comparison with pure components.

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Pisa, via Diotisalvi 2, 56126, Pisa, Italy

    M. G. Cascone, L. Lazzeri, N. Barbani, G. Polacco & P. Giusti

  2. Chemical Institute, Faculty of Engineering, University of Catania, viale A. Doria 6, 95125, Catania, Italy

    A. Pollicino

Authors
  1. M. G. Cascone
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  2. L. Lazzeri
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  3. N. Barbani
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  4. G. Polacco
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  5. A. Pollicino
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  6. P. Giusti
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Additional information

This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto, Portugal, 10–13 September.

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Cascone, M.G., Lazzeri, L., Barbani, N. et al. Dehydro-thermally cross-linked collagen-poly(vinyl alcohol) blends: mechanical, biological and surface properties. J Mater Sci: Mater Med 7, 297–300 (1996). https://doi.org/10.1007/BF00058570

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  • DOI: https://doi.org/10.1007/BF00058570

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