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Effect of the hypocholesterolemic drug AY9944 on developing central nervous system of rats: Alteration of endoplasmic reticulum in oligodendroglia

  • Published:
Journal of Neurocytology

Summary

Unusual alterations of the endoplasmic reticulum were seen in the oligodendroglia of young rats treated with AY9944. They consisted of:

  1. 1.

    random proliferation of membranes within the cytoplasm, some of them with attached ribosomes;

  2. 2.

    multi-layers of paired membranes connected to the cisternae of the rough endoplasmic reticulum which encircled the cytoplasm of oligodendroglia as a whole or focally;

  3. 3.

    formation of numerous small whorls of about 0.5 μm in diameter which are made up of two fused membranes of the rough endoplasmic reticulum.

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Authors and Affiliations

  1. Department of Pathology (Neuropathology), Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1410 Pelham Parkway South, 10461, The Bronx, New York

    Kinuko Suzuki & Joy C. Zagoren

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  1. Kinuko Suzuki
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  2. Joy C. Zagoren
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Suzuki, K., Zagoren, J.C. Effect of the hypocholesterolemic drug AY9944 on developing central nervous system of rats: Alteration of endoplasmic reticulum in oligodendroglia. J Neurocytol 2, 369–381 (1973). https://doi.org/10.1007/BF01103795

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  • DOI: https://doi.org/10.1007/BF01103795

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