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Intracellular septate desmosome-like structures in a human acoustic Schwannomain vitro

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Journal of Neurocytology

Summary

The finding of intracellular septate desmosome-like structures in a human acoustic Schwannoma maintained in an organ culture system is detailed. These structures differ in their cellular location from the intercellular septate junctional complexes which have been described in invertebrates and in a few vertebrate tissues. They also differ from the inter- and intramitochondrial septate structures which have occasionally been reported, in that they are not related to mitochondria but rather to the cell plasma membrane. Intracellular septate complexes of this type have not previously been described.

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References

  • Barros, C. andFranklin, L. E. (1968) Behaviour of the gamete membranes during sperm entry into the mammalian egg.Journal of Cell Biology 37, C13-C18.

    Google Scholar 

  • Blümcke, S. andNiedorf, H. R. (1966) Electron miscroscopic studies of Schwann cells during the Wallerian degeneration with special reference to the cytoplasmic filaments.Acta Neuropathologica (Berlin)6, 46–60.

    Google Scholar 

  • Brightman, M. W. andPalay, S. L. (1963) The fine structure of ependyma in the brain of the rat.Journal of Cell Biology 19, 415–39.

    Google Scholar 

  • Bulger, R. E. andTrump, B. F. (1968) Occurrence of repeating septate subunits between apposed cellular membranes.Experimental Cell Research 51, 587–94.

    Google Scholar 

  • Bullivant, S. andLoewenstein, W. R. (1968) Structure of coupled and uncoupled cell junctions.Journal of Cell Biology 37, 621–32.

    Google Scholar 

  • Cervós-Navarro, J., Matakas, F. andLazaro, M. C. (1968) Das Bauprinzip der Neurinome: Ein Beitrag zur Histogenese der Nerventumoren.Virchows Archiv Abt. A Pathologische Anatomie-Pathologie 345, 276–91.

    Google Scholar 

  • Cravioto, H. (1965) The role of Schwann cells in the development of human peripheral nerves.Journal of Ultrastructure Research 12, 634–51.

    Google Scholar 

  • Cravioto, H. andLockwood, R. (1968a) Long-spacing fibrous collagen in human acoustic nerve tumors.In vivo andin vitro observations.Journal of Ultrastructure Research 24, 70–85.

    Google Scholar 

  • Cravioto, H. andLockwood, R. (1968b) The behaviour of normal peripheral nerve in tissue culture.Zeitschrift für Zellforschung und mikroskopische Anatomie 90, 186–201.

    Google Scholar 

  • Cravioto, H. (1969) The ultrastructure of acoustic nerve tumours.Acta Neuropathologica (Berlin)12, 116–40.

    Google Scholar 

  • Danilova, L. V., Rokhlenko, D. K. andBodryagina, A. V. (1969) Electron microscopic study on the structure of septate and comb desmosomes.Zeitschrift für Zellforschung und mikroskopische Anatomie 100, 101–17.

    Google Scholar 

  • Farquhar, M. G. andPalade, G. E. (1963) Junctional complexes in various epithelia.Journal of Cell Biology 17, 375–412.

    Google Scholar 

  • Fisher, E. R. andVuzevski, V. D. (1968) Cytogenesis of Schwannoma (neurilemoma), neurofibroma, dermatofibroma, and dermatofibrosarcoma as revealed by electron microscopy.American Journal of Clinical Pathology 49, 141–54.

    Google Scholar 

  • Friend, D. S. andGilula, N. B. (1972) A distinctive cell contact in the rat adrenal cortex.Journal of Cell Biology 53, 148–63.

    Google Scholar 

  • Gamble, H. J. andBreathnach, A. S. (1965) An electron-microscope study of human fetal peripheral nerves.Journal of Anatomy 99, 573–84.

    Google Scholar 

  • Gilula, N. B., Branton, D. andSatir, P. (1970) The septate junction: A structural basis for intercellular coupling.Proceedings of the National Academy of Sciences 67, 213–20.

    Google Scholar 

  • Gobel, S. (1971) Axo-axonic septate junctions in the basket formations of the cat cerebellar cortex.Journal of Cell Biology 51, 328–33.

    Google Scholar 

  • Hall, S. M. andWilliams, P. L. (1970) Studies on the ‘incisures’ of Schmidt and Lanterman.Journal of Cell Science 6, 767–97.

    Google Scholar 

  • Hama, K. (1959) Some observations on the fine structure of the giant nerve fibres of the earthworm,Eisenia foetida.Journal of Biophysical and Biochemical Cytology 6, 61–6.

    Google Scholar 

  • Hand, A. R. andGobel, S. (1972) The structural organization of the septate and gap junctions ofHydra.Journal of Cell Biology 52, 397–408.

    Google Scholar 

  • Harkin, J. C. (1964) A series of desmosomal attachments in the Schwann sheath of myelinated mammalian nerves.Zeitschrift für Zellforschung und mikroskopische Anatomie 64, 189–95.

    Google Scholar 

  • Herman, M. M., Miquel, J. andJohnson, M. (1971) Insect brain as a model for the study of ageing.Acta Neuropathologica (Berlin)19, 167–83.

    Google Scholar 

  • Hilding, D. A. andHouse, W. F. (1965) ‘Acoustic neuroma’: Comparison of traumatic and neoplastic.Journal of Ultrastructure Research 12, 611–23.

    Google Scholar 

  • Hudspeth, A. J. andRevel, J. P. (1971) Coexistence of gap and septate junctions in an invertebrate epithelium.Journal of Cell Biology 50, 92–101.

    Google Scholar 

  • Johnson, R. G. andSheridan, J. D. (1971) Junctions between cancer cells in culture: Ultrastructure and permeability.Science 174, 717–19.

    Google Scholar 

  • Kalus, M. andO'neal, R. M. (1968) Organ tissue culture of a three-dimensional matrix of human fibrin foam.Archives of Pathology 86, 52–9.

    Google Scholar 

  • Lane, N. J. andTreherne, J. E. (1972) Studies on perineurial Junctional complexes and the sites of uptake of microperoxidase and lanthanum in the cockroach central nervous system.Tissue and Cell 4, 427–36.

    Google Scholar 

  • Lasansky, A. (1969) Basal junctions at synaptic endings of the turtle visual cells.Journal of Cell Biology 40, 577–81.

    Google Scholar 

  • Locke, M. (1965) The structure of septate desmosomes.Journal of Cell Biology 25, 166–8.

    Google Scholar 

  • Loewenstein, W. R. andKanno, Y. (1964) Studies on an epithelial (gland) cell junction. I. Modifications of surface membrane permeability.Journal of Cell Biology 22, 565–86.

    Google Scholar 

  • Luse, S. A. (1960) Electron microscopic studies of brain tumours.Neurology 10, 881–905.

    Google Scholar 

  • Osborne, M. P. (1972) Helical filaments in the glial cells of the locust (Schistocerca gregaria).Journal of Cell Science II, 295–303.

    Google Scholar 

  • Overton, J. (1963) Intercellular connections in the outgrowing stolon ofCordylophora.Journal of Cell Biology 17, 661–71.

    Google Scholar 

  • Pearse, A. G. E. andWelsch, U. (1968) Ultrastructural characteristics of the thyroid C cells in the summer, autumn and winter states of the hedgehog (Erinaceus europaeus L.), with some reference to other mammalian species.Zeitschrift für Zellforschung und mikroskopische Anatomie 92, 596–609.

    Google Scholar 

  • Peters, A. andMuir, A. R. (1959) The relationship between axons and Schwann cells during development of peripheral nerves in the rat.Quarterly Journal of Experimental Physiology 44, 117–30.

    Google Scholar 

  • Peters, A., Palay, S. L. andWebster, Def. (1970)The fine structure of the nervous system. The cells and their processes. New York: Harper & Row, Hoeber Medical Division.

    Google Scholar 

  • Pillai, P. A. (1964) A banded structure in the connective tissue of nerve.Journal of Ultrastructure Research 11, 455–68.

    Google Scholar 

  • Pineda, A. (1964) Submicroscopic structure of acoustic tumours.Neurology 14, 171–84.

    Google Scholar 

  • Pineda, A. (1965) Collagen formation by principal cells of acoustic tumours.Neurology 15, 536–47.

    Google Scholar 

  • Poirier, J. andEscourolle, R. (1967) Ultrastructure des neurinomes de l'acoustique.Zeitschrift für mikroskopisch-anatomische Forschung 76, 509–29.

    Google Scholar 

  • Potts, M. (1966) The attachment phase of ovoplantation.American Journal of Obstetrics and Gynecology 96, 1122–8.

    Google Scholar 

  • Raimondi, A. J. andBeckman, F. (1967) Perineurial fibroblastomas: their fine structure and biology.Acta Neuropathologica (Berlin)8, 1–23.

    Google Scholar 

  • Raimondi, A. J., Mullan, S. andEvans, J. P. (1962) Human brain tumours: An electronmicroscopic study.Journal of Neurosurgery 19, 731–53.

    Google Scholar 

  • Ramsey, H. J. (1965) Fibrous long-spacing collagen in tumours of the nervous system.Journal of Neuropathology and Experimental Neurology 24, 40–8.

    Google Scholar 

  • Reynolds, E. S. (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.Journal of Cell Biology 17, 208–12.

    Google Scholar 

  • Richardson, K. C., Jarett, L. andFinke, E. H. (1960) Embedding in epoxy resins for ultrathin sectioning in electron microscopy.Stain Technology 35, 313–23.

    Google Scholar 

  • Rosenbluth, J. andPalay, S. L. (1961) The fine structure of nerve cell bodies and their myelin sheaths in the eighth nerve ganglion of the goldfish.Journal of Biophysical and Biochemical Cytology 9, 853–78.

    Google Scholar 

  • Rubinstein, L. J., Herman, M. M. andFoley, V. L. (1973)In vitro characteristics of human glioblastomas maintained in organ culture systems. Light microscopy observations.American Journal of Pathology 71, 61–76.

    Google Scholar 

  • Rupec, M. andBraun-Falco, O. (1968) Septiert aussehende Zwischzellkontakte in normaler menschlicher Epidermis.Experientia (Basel)24, 1038.

    Google Scholar 

  • Satir, P. andGilula, N. B. (1970) The cell junction in the lamellibranch gill ciliated epithelium. Localization of pyroantimonate precipitate.Journal of Cell Biology 47, 468–87.

    Google Scholar 

  • Schulz, R. A. andHilding, D. A. (1970) Nerve fibre growth and myelination in von Recklinghausen eighth nerve tumour tissue.Journal of Neuropathology and Experimental Neurology 29, 105–18.

    Google Scholar 

  • Sotelo, C. andLlinás, R. (1972) Specialized membrane junctions between neurons in the vertebrate cerebellar cortex.Journal of Cell Biology 53, 271–89.

    Google Scholar 

  • Tani, E., Ametani, T., Higashi, N. andFujihara, E. (1971) Atypical cristae in mitochondria of human glioblastoma multiforme cells.Journal of Ultrastructure Research 36, 211–21.

    Google Scholar 

  • Thomas, P. K. (1964) The deposition of collagen in relation to Schwann cell basement membrane during peripheral nerve regeneration.Journal of Cell Biology 23, 375–82.

    Google Scholar 

  • Tsubo, I. andBrandt, P. W. (1962) An electron microscopic study of the malpighian tubules of the grasshopper,Dissosteira carolina.Journal of Ultrastructure Research 6, 28–35.

    Google Scholar 

  • Waggener, J. D. (1966) Ultrastructure of benign peripheral nerve sheath tumours.Cancer 19, 699–709.

    Google Scholar 

  • Watson, M. L. (1958) Staining of tissue sections for electron microscopy with heavy metals.Journal of Biophysical and Biochemical Cytology 4 475–79.

    Google Scholar 

  • Wechsler, W. andHossmann, K. A. (1965) Zur Feinstruktur menschlicher Acusticusneurinome.Beitraege zur pathogischen anatomic und zur allgemeinen Pathologie 132, 319–43.

    Google Scholar 

  • Wiener, J., Spiro, D. andLoewenstein, W. R. (1964) Studies on an epithelial (gland) cell junction. II. Surface structure.Journal of Cell Biology 22, 587–598.

    Google Scholar 

  • Wood, R. L. (1959) Intercellular attachment in the epithelium of theHydra as revealed by electron microscopy.Journal of Biophysical and Biochemical Cytology 6, 343–52.

    Google Scholar 

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Conley, F.K., Herman, M.M. Intracellular septate desmosome-like structures in a human acoustic Schwannomain vitro . J Neurocytol 2, 457–464 (1973). https://doi.org/10.1007/BF01103801

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  • DOI: https://doi.org/10.1007/BF01103801

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