Conclusions
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1.
A series of amides of N-substitutedα-pyrrolidine carboxylic acids are prepared for comparachemotherapeutic tests.
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2.
The antiviral activity of amides of N-substitutedα-pyrrolidine carboxylic acids are studied with respect to influenza virus type A. A connection between the chemical structure of the amides and their antiviral activity is followed in experiments in vitro and in vivo.
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T. Ueda and S. Kato, Japanese Patent No. 2681 (1961); Ref. Zh. Khimiya, No. 7, No. 7L317 (1962).
T. Ueda, S. Kato, and S. Toesima, Japanese Patent No. 7296 (1960); Ref. Zh. Khimiya, No. 2, No. 2L335 (1962).
T. Ueda and S. Kato, Japanese Patent No. 2678 (1961); Ref. Zh. Khimiya, No. 7, No. 7L313 (1962).
A. S. Lebedeva, A. M. Likhosherstov, and A. P. Skoldinov, Zh. Obshch. Khim.,34, 3806 (1964).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 4, pp. 22–25, April, 1968.
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Lebedeva, A.S., Tolmacheva, N.S., Yushchenko, N.A. et al. Synthesis and antiviral activity of certain aliphatic amides of N-substituted α-pyrrolidine carboxylic acids. Pharm Chem J 2, 195–197 (1968). https://doi.org/10.1007/BF00759879
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DOI: https://doi.org/10.1007/BF00759879