Summary
Cyclosporin A was produced in a low foaming semi-synthetic media by carrageenan-entrappedTolypocladium inflatum in an airlift bioreactor with an external circulation loop. The cyclosporin A recovered by a single ethyl acetate extraction was essentially free of contaminating media and endogenously produced microbial products.
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Foster, B.C., Coutts, R.T., Pasutto, F.M. et al. Production of cyclosporin a by carrageenan-immobilized tolypocladium inflatum in an airlift reactor with external loop. Biotechnol Lett 5, 693–696 (1983). https://doi.org/10.1007/BF01386364
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DOI: https://doi.org/10.1007/BF01386364