Summary
Copper(II) complexes of the type [Cu(L)X], where L=tridentate anion of 2-acetylpyridineN 4-diethyl thiosemicarbazone and X=C1 or Br, were screened against seven fungal strains pathogenic to man viz.Aspergillus niger, Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Tricophyton rubrum, Epidermophyton foccosum andMicrosporum canis. The greater growth inhibition exhibited by the bromo complex can be explained on the basis of its lower Cu(II)/Cu(I) redox couple and greater covalent bonding. These compounds represent a novel class of metal-based antifungal agents which provide opportunities for a large number of synthetic variations for modulation of the activities.
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Kumbhar, A.S., Padhye, S.B., Saraf, A.P. et al. Novel broad-spectrum metal-based antifungal agents. Biol Metals 4, 141–143 (1991). https://doi.org/10.1007/BF01141304
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DOI: https://doi.org/10.1007/BF01141304