Summary
Mast cell granules contain a variety of N-linked saccharides. Heterogeneity of the expression of these saccharides in mast cells was studied in rodent and human tissues which were so selected as to contain all the mast cell subsets previously identified using other criteria. Dermal and intestinal mucosal mast cells were stained with lectins using an avidin-biotin system. It was found that dermal and subepidermal mast cells in the rat and mouse, and mucosal and dermal human mast cells showed very similar lectin binding properties to each other, with a fine variation in the inlensity of staining with certain lectins. Rat mucosal mast cells, however, showed a distinctive pattern of lectin binding which was not seen in mast cells from any other tissue studied. The chemical basis of the differences seen were deduced and the possible significance of these structural variations is discussed.
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Roberts, I.S.D., Jones, C.J.P. & Stoddart, R.W. Lectin histochemistry of the mast cell: Heterogeneity of rodent and human mast cell populations. Histochem J 22, 73–80 (1990). https://doi.org/10.1007/BF01885784
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DOI: https://doi.org/10.1007/BF01885784