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Cytokines in animal models of cancer

  • Published:
Biotherapy

Abstract

Cytokines are a complex family of mediators that play a wide role in development, immunity, inflammation and tissue repair. Their use in therapy is still in its infancy and animal models have a key role to play in optimizing doses and schedules. Whilst xenogeneic and syngeneic transplantable systems have traditionally been used to look at the effects of cytokines in tumour models, oncogene transgenic mice prone to develop cancer, may now have a role to play. Moreover, gene therapy has allowed the investigation of ectopically expressed high and continous levels of cytokines. We will attempt to review the literature on the effect of cytokines and their combinations in these models of cancer.

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Abbreviations

CML:

chronic myeloid leukemia

5-FU:

5-fluoruracil

FLC:

Friend leukemia cells

i.p.:

intraperitoneal

IFN:

interferon

IL:

interleukins

LAK:

lymphokine activated killer

s.c:

subcutaneous

SCCHN:

human squamous cell carcinoma of the head and neck

TNF:

tumour necrosis factor

PEG:

polyethylene-glycol

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  1. Biological Therapies Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK

    Frances Burke & Frances R. Balkwill

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Burke, F., Balkwill, F.R. Cytokines in animal models of cancer. Biotherapy 8, 229–241 (1996). https://doi.org/10.1007/BF01877209

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