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A pooled analysis of thyroid cancer studies. V. Anthropometric factors

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Abstract

Objective: To assess the relation between anthropometric factors and thyroid cancer risk in a pooled analysis of individual data from 12 case–control studies conducted in the US, Japan, China and Europe.

Methods: 2056 female and 417 male cases, 3358 female and 965 male controls were considered. Odds ratios (OR) were derived from logistic regression, conditioning on age, A-bomb exposure (Japan) and study, and adjusting for radiotherapy.

Results: Compared to the lowest tertile of height, the pooled OR was 1.2 for females for the highest one, and 1.5 for males, and trends in risk were significant. With reference to weight at diagnosis, the OR for females was 1.2 for the highest tertile, and the trend in risk was significant, whereas no association was observed in males. Body mass index (BMI) at diagnosis was directly related to thyroid cancer risk in females (OR = 1.2 for the highest tertile), but not in males. No consistent pattern of risk emerged with BMI during the late teens. Most of the associations were observed both for papillary and follicular cancers, and in all age groups. However, significant heterogeneity was observed across studies.

Conclusions: Height and weight at diagnosis are moderately related to thyroid cancer risk.

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Author information

Author notes

  1. Maria Rosaria Galanti

    Present address: Tobacco Prevention Centre, SE-14157, Huddinge, Sweden)

Authors and Affiliations

  1. Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy

    Luigino Dal Maso & Silvia Franceschi

  2. Istituto di Ricerche Farmacologiche “Mario Negri”, 20157, Milan, Italy

    Carlo La Vecchia & Eva Negri

  3. Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, 20133, Milan, Italy

    Carlo La Vecchia

  4. Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90033-0800, USA

    Susan Preston-Martin & Wendy Mack

  5. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 20852-7238, USA

    Elaine Ron & Steven D. Mark

  6. Registre Vaudois des Tumeurs, CH-1011, Lausanne, Switzerland

    Fabio Levi

  7. Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA

    Anne McTiernan

  8. Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, 96813, USA

    Laurence Kolonel

  9. Radiation Effects Research Foundation, Hiroshima, 732, Japan

    Kiyohiko Mabuchi

  10. Shanghai Cancer Institute, Shanghai, People's Republic of China

    Fan Jin

  11. Division of Occupational and Environmental Medicine, Faculty of Health Sciences, Linköping University, SE-581 85, Linköping, Sweden

    Gun Wingren

  12. Department of Cancer Epidemiology, University Hospital, SE-57185, Uppsala, Sweden

    Maria Rosaria Galanti

  13. Department of Oncology, Karolinska Institute and Stockholms Sjukhem, SE-112 35, Stockholm, Sweden

    Arne Hallquist

  14. Cancer Registry of Norway, Montebello, NO-3010, Oslo, Norway

    Eystein Glattre

  15. Institute of Community Medicine, University of TromsØ, NO-9037, TromsØ, Norway

    Eiliv Lund

  16. Institute of Preventive Medicine, GR-145 61, Kifissia, Greece

    Dimitrios Linos

Authors
  1. Luigino Dal Maso
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  2. Carlo La Vecchia
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  3. Silvia Franceschi
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  4. Susan Preston-Martin
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  5. Elaine Ron
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  6. Fabio Levi
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  7. Wendy Mack
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  8. Steven D. Mark
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  9. Anne McTiernan
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  10. Laurence Kolonel
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  11. Kiyohiko Mabuchi
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  12. Fan Jin
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  13. Gun Wingren
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  14. Maria Rosaria Galanti
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  15. Arne Hallquist
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  16. Eystein Glattre
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  17. Eiliv Lund
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  18. Dimitrios Linos
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  19. Eva Negri
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Maso, L.D., Vecchia, C.L., Franceschi, S. et al. A pooled analysis of thyroid cancer studies. V. Anthropometric factors. Cancer Causes Control 11, 137–144 (2000). https://doi.org/10.1023/A:1008938520101

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