Abstract
We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
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Palanduz, Ş., Sever, M., öztürk, Ş. et al. Genotoxic potential of cyclosporin A in patients with renal transplantation. Cell Biol Toxicol 15, 13–17 (1999). https://doi.org/10.1023/A:1007594421458
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DOI: https://doi.org/10.1023/A:1007594421458