Abstract
Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. the hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.
Similar content being viewed by others
References
Berger, R., Bloomfield, C. D. & Sutherland, G. R., 1985. Report of the committee on chromosome rearrangements in neoplasia and on fragile sites (HGM8). Cytogenet. Cell Genet. 40: 430–435.
Bullerdiek, J., Bartnitzke, S., Kahrs, E. & Schloot, W., 1985a. Further evidence for nonrandom chromosome changes in carcinoma cells. A report of 28 cases. Cancer Genet. Cytogenet. 16: 33–43.
Bullerdiek, J., Bartnitzke, S., Kahrs, E. & Schloot, W., 1985b. Cytogenetic observations on two ovarian carcinomas with double minutes, one with a 6q marker chromosome. Cytobios 42: 15–24.
Bullerdiek, J. & Bartnitzke, S., 1985. The deleted long arm of chromosome 6: A secondary chromosome abnormality in solid tumors and lack of congenital aberrations monosomic for part of the critical segment. Cancer Genet. Cytogenet. 18: 183–185.
Bullerdiek, J., Böschen, C. & Bartnitzke, S., 1987. Aberrations of chromosome Nr 8 in mixed salivary gland tumors—Cytogenetic findings on seven cases. Cancer Genet. Cytogenet 24: 205–212.
Gibas, Z., Prout, G. R., Conolly, J. G., Pontes, J. E. & Sandberg, A. A., 1984. Nonrandom chromosomal changes in transitional cell carcinoma of the bladder. Cancer Res. 44: 1257–1264.
Hamerton, J. L., Povey, S. & Morton, N. E., 1984. Report of the committee on the genetic constitution of chromosome 1 (HGM 7). Cytogenet. Cell Genet. 37: 3–21.
Mark, J., Dahlenfors, R., Ekedahl, C. & Stenman, G., 1980. The mixed salivary gland tumor—a normally benign human neoplasm frequently showing specific chromosomal abnormalities. Cancer Genet. Cytogenet. 2: 231–241.
Mark, J., Dahlenfors, R. & Ekedahl, C., 1981. Chromosomal deviations and their specificity in human mixed salivary gland tumors. Anticancer Res. 1: 49–57.
Mark, J., Dahlenfors, R., Ekedahl, G. & Stenman, G., 1982. Chromosomal patterns in a human benign neoplasm, the mixed salivary gland tumor. Hereditas 96: 141–148.
Mark, J., Dahlenfors, R. & Ekedahl, C., 1983a. Cytogenetics of the mixed salivary gland tumor. Hereditas 99: 115–148.
Mark, J., Dahlenfors, R. & Ekedahl, C., 1983b. Specificity and implications of ring chromosomes and dicentrics in benign salivary gland tumors. Acta path. microbiol. immunol. scand. Sect. A 91: 397–402.
Mitelman, F., 1985. Catalogue of chromosome aberrations in cancer. 2nd edition in: Sandberg, A. A. (ed.), Progress and topics in cytogenetics, vol. 5, Alan R. Liss, New York.
Stenman, G., 1983. Cytogenetic studies on human salivary gland neoplasms with special reference to chromosomal patterns in the benign mixed tumor. Thesis, Götehorg.
Stenman, G., Mark, J. & Ekedahl, C., 1984. Relationships between chromosomal patterns and proto-oncogenes in human benign mixed salivary gland tumors. Tumor Biology 5: 103–117.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bullerdiek, J., Raabe, G., Bartnitzke, S. et al. Structural rearrangements of chromosome Nr 8 involving 8q12—a primary event in pleomorphic ademona of the parotid gland. Genetica 72, 85–92 (1987). https://doi.org/10.1007/BF00123166
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00123166