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Corneal graft after drug-induced toxic epidermal necrolysis (Lyell's disease)

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Abstract

Toxic epidermal necrolysis (TEN) is a clinical syndrome characterizedby extensive epidermal loss similar to that found in scalding. Drugsensitization is generally considered to be the mechanism leading tothis condition. Severe ocular manifestations are present in nearlyall patients.We report a case of TEN with severe ocular involvement, on whom twopenetrating keratoplasties were performed in the same eye.Although the prognosis of keratoplasty is reported to be poor whencicatricial changes are present, after the second graft, our patient'ssymptoms of pain decreased and her visual acuity from lightperception improved to 20/40. The graft remains transparant underimmunosuppressive therapy twenty-three months after surgery.

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References

  1. Lyell A. Toxic epidermal necrolysis: An eruption resembling scalding of the skin. Br J Dermatol 1956; 68: 355–361

    Google Scholar 

  2. Wilkins J, Morrison L, White CR. Oculocutaneous manifestations of the erythema multiforme / Stevens-Johnson syndrome / Toxic epidermal necrolysis spectrum. In: Grant-Kels JM, Rothe MJ, Kels B (eds) Dermatologic Clinics. Phyladelphia W B Saunders Co, 1992; 10: 571–582.

    Google Scholar 

  3. Björnberg A, Bjórnberg K, Gilsen H. Toxic epidermal necrolysis with ophthalmic complications. Acta Ophthalmol 1964; 42: 1084–1095.

    Google Scholar 

  4. Kozarsky AM, Knight SH, Waring GO III. Clinical results with a ceramic keratoprosthesis placed through the eyelid. Ophthalmology 1987; 94: 904–911.

    Google Scholar 

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Authors and Affiliations

  1. Instituto de Oftalmología de Galicia, Hospital Clínico Universitario, Spain

    M. Teresa Rodrígues-Ares, Francisco González, M. Victoria De Rojas, Carmela Capeans & Manual Sánchez-Salorio

  2. Departamento de Fisiología, Facultad de Medicina, Santiago de Compostela, Spain

    Francisco González

Authors
  1. M. Teresa Rodrígues-Ares
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  2. Francisco González
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  3. M. Victoria De Rojas
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  4. Carmela Capeans
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  5. Manual Sánchez-Salorio
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Rodrígues-Ares, M.T., González, F., De Rojas, M.V. et al. Corneal graft after drug-induced toxic epidermal necrolysis (Lyell's disease). Int Ophthalmol 21, 39–41 (1997). https://doi.org/10.1023/A:1005833704317

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  • DOI: https://doi.org/10.1023/A:1005833704317

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