Abstract
The formation of inclusion compounds between violacein andβ-cyclodextrin was studied by diffusion and circulardichroism measurements. The present work was undertaken to explore the feasibilityof the β-cyclodextrin in reducing the toxicity and enhancing the antitumoral efficacy ofviolacein by forming an inclusion complex. The results of the two experimentsare in good agreement, suggesting the formation of 1 : 1 and 1 : 2 complexes.The diffusion coefficient measurements enabled estimates of the sizes of the complexesinvolved. From the circular dichroism and computational calculations it was possibleto view a preference for inclusion of the most polar part of the molecule to form a1 : 2 inclusion complex. We expect that this work proves the potential of thesetechniques to determining complex stoichiometry.
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De Azevedo, M.B.M., Alderete, J.B., Lino, A.C.S. et al. Violacein/β-Cyclodextrin Inclusion Complex Formation Studied by Measurements of Diffusion Coefficient and Circular Dichroism. Journal of Inclusion Phenomena 37, 67–74 (2000). https://doi.org/10.1023/A:1008186706573
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DOI: https://doi.org/10.1023/A:1008186706573