Skip to main content
SpringerLink
Log in

Preparation and evaluation of99mTc-thiodiglycolic acid (TDGA) for renal function studies

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Methods for the preparation and analysis of a new renal radiopharmaceutical,99mTc-thiodiglycolic acid (TDGA), are reported. The kit for Tc-TDGA contains a lypophilized acidic (pH 2.5) mixture of 5 mg TDGA and 0.05 mg SnCl2·2H2O. Acetate buffer has been found to be a suitable solvent for paper chromatography of99mTc-TDGA. The results of the quantitative organ distribution studies in rats and rabbits indicated the characteristics of99mTc-TDGA to be intermediate to the renal tubular agent131I-Hippuran and the GFR agent99mTc-DTPA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. R. FRITZBERG, W. C. KLINGESMITH III, W. P. WHITNEY, C. C. KUNI, J. Nucl. Med., 22 (1981) 258.

    PubMed  Google Scholar 

  2. A. R. FRITZBERG, C. C. KUNI, W. C. KLINGENSMITH III, J. STEVENS, W. P. WHITNEY, J. Nucl. Med., 23 (1982) 592.

    PubMed  Google Scholar 

  3. A. R. FRITZBERG, S. KASINA, D. ESHIMA, D. L. JOHNSON, J. Nucl. Med., 27 (1986) 111.

    PubMed  Google Scholar 

  4. R. F. SCHNEIDER, G. SUBRAMANIAN, T. A. FELD, J. G. McAFEE, C. ZAPF-LONGO, E. PALLADINO, F. D. THOMAS, J. Nucl. Med., 25 (1984) 223.

    PubMed  Google Scholar 

  5. J. G. McAFEE, G. SUBRAMANIAN, R. F. SCHNEIDER, M. ROSKOPF, B. LYONS, C. RITTER, C. ZAPF-LONGO, E. PALLADINO, F. D. THOMAS, J. Nucl. Med., 26 (1985) 375.

    PubMed  Google Scholar 

  6. A. TAYLOR Jr., D. ESHIMA, N. ALAZAKI, Eur. J. Nucl. Med., 12 (1987) 510.

    Article  PubMed  Google Scholar 

  7. G. R. BONIFACE, M. R. SURESH, D. J. WILLANS, Y. K. TAM, A. SHYSH, B. M. LONGENECKER, A. A. NOUJAIM, J. Nucl. Med., 27 (1986) 668.

    PubMed  Google Scholar 

  8. C. R. A. BEVIS, R. S. LAWSON, R. A. SHIELDS, H. J. TESTA, Nucl. Med. Commun., 4 (1983) 386.

    Google Scholar 

  9. C. R. A. BEVIS, R. S. LAWSON, R. A. SHIELDS, H. J. TESTA, Nucl. Med. Commun., 5 (1984) 513.

    PubMed  Google Scholar 

  10. B. N. AMES, et al., (1973) Proc. Natl. Acad. Sci. U.S. 70, 1973, p. 2281.

    Google Scholar 

  11. S. A. BALAKRISHNAN, P. M. PANDEY, S. M. GAITONDE, R. S. MANI, DAE Symp. on Radiochemistry and Radiation Chemistry, Tirupathi, BARC, 1986, p. 490.

  12. A. TOTTSEHALK, HARPER, P. V. LATHROP, Pharmacodynamics of99mTc. Radioactive pharmaceutical Symp. U.S. Atomic Energy Commission 6, 1966, p. 347.

    Google Scholar 

  13. O. INOUE, I. IKEDA, K. KURATA, Radioisotopes, 25 (1976) 24.

    Google Scholar 

  14. D. P. NOWOTNIK, R. D. PICKETT, C. D. R. ALLEN, Eur. J. Nucl. Med., 11 (1985) 285.

    Article  PubMed  Google Scholar 

  15. L. L. Y. HWANG, N. RONCE, N. A. SOLOMAN, J. STEIGMAN, Int. J. Appl. Radiation Isotopes, 35 (1984) 825.

    Article  Google Scholar 

  16. N. RAMAMOORTHY, Ph. D. Thesis, University of Bombay, 1987.

Download references

Author information

Authors and Affiliations

  1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, 400 085, Bombay, (India)

    N. Ramamoorthy, S. A. Balakrishnan, S. M. Gaitonde & P. M. Pandey

  2. Radiation Medicine Centre, Bhabha Atomic Research Centre, TMC Annex Parel, 400 012, Bombay, (India)

    U. N. Nayak, M. C. Patel, R. B. Patel & P. Ramanathan

Authors
  1. N. Ramamoorthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. A. Balakrishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. M. Gaitonde
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. M. Pandey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. U. N. Nayak
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. C. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. B. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. Ramanathan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ramamoorthy, N., Balakrishnan, S.A., Gaitonde, S.M. et al. Preparation and evaluation of99mTc-thiodiglycolic acid (TDGA) for renal function studies. Journal of Radioanalytical and Nuclear Chemistry, Articles 134, 423–431 (1989). https://doi.org/10.1007/BF02278279

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02278279

Keywords

Search

Navigation