Skip to main content
Log in

Lipophilic technetium complexes

IV. Neutral, lipid-soluble technetium complexes with dithioligands containing Tc=O and Tc≡N cores. An in vitro study

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

A series of technetium complexes with different alkyl dithiocarbamates, dithiophosphates and xanthates has been prepared at tracer level (10−4 molar) starting from hydrazine-reduced pertechnetate and Tc(V) gluconate, respectively. Solution studies show the complexes to be neutral, lipid-soluble tracers. Their in vitro properties can be varied in a wide range by variation of alkyl substitution of the ligands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. U ABRAM, H. SPIES, W. GÖRNER, R. KIRMSE, J. STACH, Inorg. Chim. Acta, 109 (1985) L9.

    Google Scholar 

  2. W. H. OLDENDORF, J. Nucl. Med., 19 (1978) 1182.

    Google Scholar 

  3. M. D. LOBERG, E. H. CORDER, A. T. FIELDS, P. S. CALLERY, J. Nucl. Med., 20 (1979) 1181.

    PubMed  Google Scholar 

  4. A. YOKOYAMA, A. YAMADA, Y. ARANO, K. HORIUCHI, K. YAMAMOTO, K. TORIZUKA, Proc. 1st Intern. Symp. on Technetium in Chemistry and Nuclear Medicine, Padua 1982, p. 109.

  5. H. F. KUNG, M. MOLNAR, J. BILLINGS, R. WICKS, M. BLAU, J. Nucl. Med., 25 (1984) 339.

    Google Scholar 

  6. H. SPIES, H. J. PIETZSCH, U. ABRAM, J. Radioanal. Nucl. Chem. Letters, 85 (1984) 339.

    Google Scholar 

  7. D. E. TROUTNER, W. A. VOLKERT, T. J. HOFFMAN, R. A. HOLMES, Intern. J. Appl. Radiation Isotopes, 35 (1984) 467.

    Google Scholar 

  8. W. A. VOLKERT, T. J. HOFFMAN, R. M. SEGER, D. E. TROUTNER, R. A. HOLMES, Eur. J. Nucl. Med., 9 (1984) 511.

    PubMed  Google Scholar 

  9. S. HOLM, A. R. ANDERSEN, S. VORSTRUP, N. A. LASSEN, O. B. PAULSEN, R. A. HOLMES, J. Nucl. Med., 26 (1985) 1129.

    PubMed  Google Scholar 

  10. S. JURISSON, E. SCHLEMPER, D. TROUTNER, L. CANNING, D. P. NOVOTNIK, J. Nucl. Med. All. Sci., 29 (1985) 201.

    Google Scholar 

  11. G. NECHVATAL, L. R. CANNING, S. A. CUMMING, D. P. NOVOTNIK, R. D. PICKETT, B. HIGLEY, R. D. NEIRINKX, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 208.

    Google Scholar 

  12. D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, G. NECHVATAL, I. M. PIPER, R. D. PICKETT, R. D. NEIRINKX, P. J. ELL, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 209.

    Google Scholar 

  13. D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, R. C. HARRISON, B. HIGLEY, G. NECHVATAL, R. D. PICKETT, I. M. PIPER, V. J. BAYNE, A. M. FORSTER, P. S. WEISNER, R. D. NEIRINKX, W. A. VOLKERT, D. E. TROUTNER, R. A. HOLMES, Nucl. Med. Comm., 6 (1985) 499.

    Google Scholar 

  14. H. F. KUNG, F. BLAU, J. Nucl. Med. 21 (1980) 147.

    PubMed  Google Scholar 

  15. H. F. KUNG, F. BLAU, J. Med. Chem., 23 (1980) 1127.

    PubMed  Google Scholar 

  16. H. S. WINCHELL, R. M. BALDWIN, T. H. LIN, J. Nucl. Med., 21 (1980) 940.

    PubMed  Google Scholar 

  17. H. F. KUNG, K. M. TRAMPOSCH, M. BLAU, J. Nucl. Med., 24 (1983) 66.

    PubMed  Google Scholar 

  18. K. M. TRAMPOSCH, H. F. KUNG, M. BLAU, J. Med. Chem., 26 (1983) 121.

    PubMed  Google Scholar 

  19. T. H. LIN, B. M. WAR, J. L. WU, J. Nucl. Med., 25 (1984) 122.

    Google Scholar 

  20. L. A. EPPS, H. D. BURN, S. Z. LEVER, H. W. GOLDFARB, T. M. KERVITSKY, D. F. WONG, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med. All. Sci., 29 (1985) 196.

    Google Scholar 

  21. S. Z. LEVER, H. D. BURN, T. M. KERVITSKY, W. H. GOLDFARB, D. W. WOO, D. F. WONG, L. A. EPPS, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med., 26 (1985) 1287.

    PubMed  Google Scholar 

  22. J. BALDAS, J. BONNYMAN, Intern. J. Appl. Radiation Isotopes, 36 (1985) 133.

    Google Scholar 

  23. U. ABRAM, H. SPIES, Inorg. Chim. Acta, 94 (1984) L3.

    Google Scholar 

  24. B. JOHANNSEN, H. SPIES, Chemistry and Radiopharmacology of Technetium Compounds (in German), Rossendorf, 1981.

  25. J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, M. F. MACKAY, J. Chem. Soc. Dalton Trans., (1981) 1798.

  26. B. JOHANNSEN, Intern. J. Appl. Radiation Isotopes, 33 (1982) 429.

    Google Scholar 

  27. B. JOHANNSEN, R. BERGER, K. SCHOMÄCKER, Radiochem. Radioanal. Letters, 42 (1980) 177.

    Google Scholar 

  28. L. KADEN, B. LORENZ, K. SCHMIDT, H. SPRINZ, M. WAHREN, Isotopenpraxis, 17 (1981) 175.

    Google Scholar 

  29. J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, Eur. J. Nucl. Med., 7 (1982) 187.

    PubMed  Google Scholar 

  30. H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 33 (1979) L113.

    Google Scholar 

  31. H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 48 (1981) 255.

    Google Scholar 

  32. J. BALDAS, J. BONNYMAN, J. Nucl. Med. All. Sci., 29 (1985) 187.

    Google Scholar 

  33. S. ABRAM, U. ABRAM, H. SPIES, R. MÜNZE, Intern. J. Appl. Radiation Isotopes, 36 (1985) 653.

    Google Scholar 

  34. H. S. TROP, Ph. D. Thesis, Massachusetts Intstitute of Technology, 1979, cited in: A. DAVISON, A. G. JONES, Intern. J. Appl. Radiation Isotopes, 33 (1982) 875.

  35. G. BANDOLI, M. NICOLINI, U. MAZZI, F. REFOSCO, J. Chem. Soc. Dalton Trans., (1984) 2505.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abram, S., Abram, U., Spies, H. et al. Lipophilic technetium complexes. Journal of Radioanalytical and Nuclear Chemistry, Articles 102, 309–320 (1986). https://doi.org/10.1007/BF02047906

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02047906

Keywords

Navigation