Abstract
A series of technetium complexes with different alkyl dithiocarbamates, dithiophosphates and xanthates has been prepared at tracer level (10−4 molar) starting from hydrazine-reduced pertechnetate and Tc(V) gluconate, respectively. Solution studies show the complexes to be neutral, lipid-soluble tracers. Their in vitro properties can be varied in a wide range by variation of alkyl substitution of the ligands.
Similar content being viewed by others
References
U ABRAM, H. SPIES, W. GÖRNER, R. KIRMSE, J. STACH, Inorg. Chim. Acta, 109 (1985) L9.
W. H. OLDENDORF, J. Nucl. Med., 19 (1978) 1182.
M. D. LOBERG, E. H. CORDER, A. T. FIELDS, P. S. CALLERY, J. Nucl. Med., 20 (1979) 1181.
A. YOKOYAMA, A. YAMADA, Y. ARANO, K. HORIUCHI, K. YAMAMOTO, K. TORIZUKA, Proc. 1st Intern. Symp. on Technetium in Chemistry and Nuclear Medicine, Padua 1982, p. 109.
H. F. KUNG, M. MOLNAR, J. BILLINGS, R. WICKS, M. BLAU, J. Nucl. Med., 25 (1984) 339.
H. SPIES, H. J. PIETZSCH, U. ABRAM, J. Radioanal. Nucl. Chem. Letters, 85 (1984) 339.
D. E. TROUTNER, W. A. VOLKERT, T. J. HOFFMAN, R. A. HOLMES, Intern. J. Appl. Radiation Isotopes, 35 (1984) 467.
W. A. VOLKERT, T. J. HOFFMAN, R. M. SEGER, D. E. TROUTNER, R. A. HOLMES, Eur. J. Nucl. Med., 9 (1984) 511.
S. HOLM, A. R. ANDERSEN, S. VORSTRUP, N. A. LASSEN, O. B. PAULSEN, R. A. HOLMES, J. Nucl. Med., 26 (1985) 1129.
S. JURISSON, E. SCHLEMPER, D. TROUTNER, L. CANNING, D. P. NOVOTNIK, J. Nucl. Med. All. Sci., 29 (1985) 201.
G. NECHVATAL, L. R. CANNING, S. A. CUMMING, D. P. NOVOTNIK, R. D. PICKETT, B. HIGLEY, R. D. NEIRINKX, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 208.
D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, G. NECHVATAL, I. M. PIPER, R. D. PICKETT, R. D. NEIRINKX, P. J. ELL, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 209.
D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, R. C. HARRISON, B. HIGLEY, G. NECHVATAL, R. D. PICKETT, I. M. PIPER, V. J. BAYNE, A. M. FORSTER, P. S. WEISNER, R. D. NEIRINKX, W. A. VOLKERT, D. E. TROUTNER, R. A. HOLMES, Nucl. Med. Comm., 6 (1985) 499.
H. F. KUNG, F. BLAU, J. Nucl. Med. 21 (1980) 147.
H. F. KUNG, F. BLAU, J. Med. Chem., 23 (1980) 1127.
H. S. WINCHELL, R. M. BALDWIN, T. H. LIN, J. Nucl. Med., 21 (1980) 940.
H. F. KUNG, K. M. TRAMPOSCH, M. BLAU, J. Nucl. Med., 24 (1983) 66.
K. M. TRAMPOSCH, H. F. KUNG, M. BLAU, J. Med. Chem., 26 (1983) 121.
T. H. LIN, B. M. WAR, J. L. WU, J. Nucl. Med., 25 (1984) 122.
L. A. EPPS, H. D. BURN, S. Z. LEVER, H. W. GOLDFARB, T. M. KERVITSKY, D. F. WONG, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med. All. Sci., 29 (1985) 196.
S. Z. LEVER, H. D. BURN, T. M. KERVITSKY, W. H. GOLDFARB, D. W. WOO, D. F. WONG, L. A. EPPS, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med., 26 (1985) 1287.
J. BALDAS, J. BONNYMAN, Intern. J. Appl. Radiation Isotopes, 36 (1985) 133.
U. ABRAM, H. SPIES, Inorg. Chim. Acta, 94 (1984) L3.
B. JOHANNSEN, H. SPIES, Chemistry and Radiopharmacology of Technetium Compounds (in German), Rossendorf, 1981.
J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, M. F. MACKAY, J. Chem. Soc. Dalton Trans., (1981) 1798.
B. JOHANNSEN, Intern. J. Appl. Radiation Isotopes, 33 (1982) 429.
B. JOHANNSEN, R. BERGER, K. SCHOMÄCKER, Radiochem. Radioanal. Letters, 42 (1980) 177.
L. KADEN, B. LORENZ, K. SCHMIDT, H. SPRINZ, M. WAHREN, Isotopenpraxis, 17 (1981) 175.
J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, Eur. J. Nucl. Med., 7 (1982) 187.
H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 33 (1979) L113.
H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 48 (1981) 255.
J. BALDAS, J. BONNYMAN, J. Nucl. Med. All. Sci., 29 (1985) 187.
S. ABRAM, U. ABRAM, H. SPIES, R. MÜNZE, Intern. J. Appl. Radiation Isotopes, 36 (1985) 653.
H. S. TROP, Ph. D. Thesis, Massachusetts Intstitute of Technology, 1979, cited in: A. DAVISON, A. G. JONES, Intern. J. Appl. Radiation Isotopes, 33 (1982) 875.
G. BANDOLI, M. NICOLINI, U. MAZZI, F. REFOSCO, J. Chem. Soc. Dalton Trans., (1984) 2505.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abram, S., Abram, U., Spies, H. et al. Lipophilic technetium complexes. Journal of Radioanalytical and Nuclear Chemistry, Articles 102, 309–320 (1986). https://doi.org/10.1007/BF02047906
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02047906