Abstract
A study was made of the thermal behavior of the starting materials, their mixtures and the resulting mebendazole tablets. The thermal curves were obtained with a Shimadzu thermobalance, model TGA-50, using an air flow of 50 mL min−1 and a heating rate of 10°C min−1 in the temperature interval 30–900°C. The reaction constant velocities for the mebendazole salt and tablets were determined isothermally, using the Arrhenius expression. The thermal stability of mebendazole tablets is lower than that of the mebendazole salt, due to the presence of starch and lactose in the composition. Analysis of the data reveals that thermogravimetry is a powerful tool in pharmaceutical technology and quality control.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Wesolowski, Thermochim. Acta, 209 (1992) 223.
M. J. Hardy, Anal. Proc., 19 (1982) 556.
I. Townsend, J. Thermal Anal., 37 (1991) 2031.
A. Chauvet, J. Kadoura and J. Masse, J. Thermal Anal., 38 (1992) 1593.
G. Bettinetti, II Farmaco, 47 (1992) 681.
L. S. Bark and E. J. Greenhow, J. Thermal Anal., 38 (1992) 1729.
Author information
Authors and Affiliations
Additional information
The authors thank CNPq/PADCT for financial support.
Rights and permissions
About this article
Cite this article
Macêdo, R.O., Gouveia de Souza, A., Miriam, A. et al. Application of thermogravimetry in the quality control of mebendazole. Journal of Thermal Analysis 49, 937–941 (1997). https://doi.org/10.1007/BF01996779
Issue Date:
DOI: https://doi.org/10.1007/BF01996779