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Thermal Stability of γ-irradiated Tolbutamide

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Abstract

The thermal stability of tolbutamide before and after exposure to various γ-radiation doses was investigated. The data were followed by studying DTA, X-ray diffraction, IR, and UV absorption spectra before and after γ-irradiation. The results obtained were promising, and were explained, and discussed on the basis of γ-enhanced stabilization through recombination of free radicals.

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References

  1. K. Flory, Analyt, Profile of Drug Substances, 3 (1974) 513.

    Article  Google Scholar 

  2. J. E. F. Renolds, 'Martindale'. The Extra Pharmacopoeia, London, Pharmaceutical Press, 30th Ed., 1993 p. 270.

    Google Scholar 

  3. T. J. Manger, D. M. Wieland and J. Wu, J. Org. Chem., 47 (1982) 1484.

    Article  Google Scholar 

  4. J. P. Weichert et al., Int. J. Appl. Radial. Isot., 37 (1986) 907.

    Article  CAS  Google Scholar 

  5. G. El-Shaboury and K. Farah, Appl. Radiat Isot., 42 (1991) 1091.

    Article  CAS  Google Scholar 

  6. A. A. El-Bellihi, A. M. Abdel-Badei and El. H. M. Diefalla, Thermochim. Acta, 165 (1990) 147.

    Article  CAS  Google Scholar 

  7. R. D. Euas, 'The Atomic Nucleus' New York Mc. Graw Hill, 1967.

  8. G. J. Dienes and G. H. Vineyard, 'Radiation Effects in Solids' New York Interscience, (1957).

  9. T. Miyazaki, T. Kaneko, T. Yoshimura, A. S. Crucq and B. Tilquin, J. Pharm. Sci., 83 (1994) 86.

    Google Scholar 

  10. T. Miyazaki, J. Arai, T. Kaneko, K. Yamamoto, M. Gibella and B. Tilquin, J. Pharm. Sci., 83 (1994) 1643.

    CAS  Google Scholar 

  11. Y. A. Riberio, J. D. S. de Oliveria, M. I. G. Lels, S. A. Juiz and M. Ionashiro, J. Thermal Anal., 46 (1996) 1645.

    Article  Google Scholar 

  12. G. O. Piloyan, L. D. Ryabchikov and O. S. Novikova, Nature, (1996) 1229.

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Authors and Affiliations

  1. National Organization for Drug Control & Research, P.O. Box 29, Cairo

    M. A. El-Ries

  2. Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

    M. M. Abou Sekkina

Authors
  1. M. A. El-Ries
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  2. M. M. Abou Sekkina
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El-Ries, M.A., Abou Sekkina, M.M. Thermal Stability of γ-irradiated Tolbutamide. Journal of Thermal Analysis and Calorimetry 55, 291–300 (1999). https://doi.org/10.1023/A:1010129415876

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  • DOI: https://doi.org/10.1023/A:1010129415876

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