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The New Hypothesis on Amino Acid Complementarity and its Experimental Proof

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Abstract

During our work on the periodicity of the genetic code we proposed a new scheme of amino acid pairing [Siemion, I.Z. and Stefanowicz, P., Biosystems, 27 (1992) 77; Bull. Pol. Acad. Sci., 40 (1992) 11]. Based on this scheme, we designed and synthesized the sequences IIYTLC(Acm)GLYL (II), IIYPLC(Acm)GLYL (V), and IYPLC(Acm)GLY (VI), which are ‘antipeptides’ with respect to immunoactive fragments of TGFβ2: YIGKTPKI (III) and YYIGKTPKIE (IV). The peptide–antipeptide interaction was investigated by electrospray ionization mass spectrometry and circular dichroism methods. The results obtained indicate that peptides interact selectively with ‘antipeptides’.

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Authors and Affiliations

  1. Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, PL-50-383, Wrocław, Poland

    Piotr Stefanowicz, Renata Zbozień & Ignacy Z. Siemion

Authors
  1. Piotr Stefanowicz
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  2. Renata Zbozień
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  3. Ignacy Z. Siemion
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Stefanowicz, P., Zbozień, R. & Siemion, I.Z. The New Hypothesis on Amino Acid Complementarity and its Experimental Proof. Letters in Peptide Science 5, 329–331 (1998). https://doi.org/10.1023/A:1008882410436

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  • DOI: https://doi.org/10.1023/A:1008882410436

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