Abstract
In anin vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predictingin vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects.
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Ros, J.J.W., Van der Meer, Y.G., De Hoop, D. et al. In vitro andin vivo comparison of creams containing dithranol 0.5%. Pharmaceutisch Weekblad Scientific Edition 13, 210–214 (1991). https://doi.org/10.1007/BF01988877
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DOI: https://doi.org/10.1007/BF01988877